The purpose of this study was to establish the effect of hypoxia-inducible factor-1 (HIF-1) directly on tumor growth, independently of angiogenesis. This was done by growing wild-type mouse hepatoma cells (HEPA-1) and their HIF-1-deficient counterpart C4 as multicellular tumor spheroids and quantifying differences in growth rates and proliferative and apoptotic indices. Insulin and insulin-like...

ABSTRACTIntroduction: The emergence of COVID-19 pandemic that occurred at the end December 2019 in Wuhan, China, was a health crisis greatly affected world. Therefore, dentists and dental nurses are professionals who have very high risk being exposed to droplets aerosol particles generated during procedures. Furthermore, they also cross-infection from exposure microorganisms blood, saliva, drop...

BACKGROUND The gaps observed between the use of research evidence and policy have been reported to be based on the different methods of using research evidence in policymaking by researchers and actual policymakers. Some policies and policymaking processes may therefore be particularly well informed by research evidence compared to others. The aims of the present article are to explore the use ...

A variety of respirator filters and surgical masks were challenged with three aerosolized bacteria: Mycobacterium abscessus (M.a.) (a rod), Staphylococcus epidermidis (S.e.) (a sphere), and Bacillus subtilis (B.s.) (a rod). Tests were conducted at two flow rates (45 and 85 l./min) and two humidity levels (30 and 70%). Aerosols were measured with a total-particle, direct-reading, spectrometer an...

HEPA filters, once known as absolute filters, were originally developed as the particulate stage of a chemical, biological, radiological (CBR) filtration/adsorber unit for use by the U.S. Armed Services. In the late 1940s the U.S. Atomic Energy Commission adopted them for use for the containment of airborne radioactive particulates in the exhaust ventilation systems of experimental reactors as ...

The effective discovery of tumor-specific antigens (TSAs) holds the key for the development of new diagnostic assays and immunotherapeutic approaches against cancer. Here, we discuss our recently developed technologies, HEPA and PARSE, which allow for the systematic identification of TSAs, generating a reservoir of immunologically and clinically relevant targets.

A need for reducing the concentration of microorganisms in the air of dental operatories has been assumed. The purpose of this study was to evaluate the effectiveness of two methods of air cleaning in reducing the number ( airborne bacteria in a closed space. Tests for clearance of Bacillus subtilis spores from static and dynamic aeroso1 " were conducted in a 70 experimental room. The air clean...

This study evaluated and compared two procedures to clean lead dust and debris after lead hazard control activities were completed in housing with lead-based paint hazards. 1995 Federal guidelines prepared by the U.S. Department of Housing and Urban Development for the control of lead-based paint hazards in housing strongly recommend that after lead hazard control interventions all walls, ceili...