since 1999, many cases of crimean-congo hemorrhagic fever have been reported from different parts of iran. this study intended to define cchf seroprevalence, incidence rates, and the most important risks in sistan- baluchestan province, iran. using cluster sampling with probability proportional to size, 310 subjects were selected from various districts of zahedan and zabol in the northern part ...

background: crimean-congo hemorrhagic fever (cchf) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. hypoxia inducible factor-1α (hif-1α) and vascular endothelial growth factor-a (vegf-a) play an important role both in the inflamma­tory process and plasma leakage. the aim of this study was to de...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...

case presentation this article presents a 56-year-old woman from guilan province, the north of iran and the southern coast of the caspian sea, who admitted to the hospital with acute fever, severe headache, thrombocytopenia, anemia, epigastric pain, myalgia, nausea and vomiting. conclusions we recognized that the case was co-infected by cchf and leptospirosis. introduction infectious diseases a...

ebola hemorrhagic fever (ehf) was first reported in 1976 with two concurrent outbreaks of acute viral hemorrhagic fever centered in yambuku (near the ebola river), democratic republic of congo, and also in nzara, sudan. the current outbreak of the ebola virus was started by reporting the first case in march 2014 in the forest regions of southeastern guinea. due to raising infection rates of ove...

results upon the results from literature search, the researchers found that human is the main reservoir for this virus. there are four serotypes of virus. infection with one serotype cannot protect human against the other three serotypes. dengue fever begins suddenly with an onset of an influenza-like syndrome and sometimes progresses to severe form of the disease. treatment is supportive and i...

Chronic administration of estrogen to the Fischer 344 (F344) rat induces growth of large, hemorrhagic pituitary tumors. Ten weeks of diethylstilbestrol (DES) treatment caused female F344 rat pituitaries to grow to an average of 109.2 +/- 6.3 mg (mean +/- SE) versus 11.3 +/- 1.4 mg for untreated rats, and to become highly hemorrhagic. The same DES treatment produced no significant growth (8.9 +/...

Although 17β-estradiol (E2) treatment following hemorrhagic shock or ischemic reperfusion prevents organs from dysfunction and injury, the precise mechanism remains unknown. We hypothesize that the E2-mediated attenuation of liver injury following hemorrhagic shock and fluid resuscitation occurs via the p38 mitogen-activated protein kinase (MAPK)-dependent heme oxygenase (HO)-1 pathway. After a...

Pituitary apoplexy is a clinical syndrome with unknown pathogenesis. Therefore, identifying the underlying mechanisms is of high clinical relevance. Tumor necrosis factor alpha (TNF-α) is a critical cytokine mediating various hemorrhagic events, but little is known about its involvement in pituitary apoplexy. Here we show that TNF-α may be an important regulator of hemorrhagic transformation in...

BACKGROUND AND PURPOSE Intracranial hemorrhage is the most severe complication of brain arteriovenous malformation treatment. We report our rate of hemorrhagic complications after endovascular treatment and analyze the clinical significance and potential mechanisms, with emphasis on cases of delayed hemorrhage after uneventful embolization. MATERIALS AND METHODS During a 10-year period, 846 e...