Direct haemoperfusion with polymyxin B-immobilized fibre (PMX-F) is a promising treatment for Gram-negative sepsis in critically ill patients. Indeed, it has been used routinely in Japan for a decade. Recent evidence presented in this journal suggests that PMX-F can have a positive impact on outcome in patients with sepsis, although other reports in the literature have presented confusing or ev...

Chronic and acute extracorporeal detoxification treatments, such as haemodialysis, haemofiltration, haemodiafiltration or haemoperfusion, clearly have become parts of the standard armamentarium of modern medicine. The necessary technical equipment has been transformed in the course of the last decades from prototype-like monsters (which nobody dared to touch without thorough education) to handy...

Abstract Background and Aims Adsorption is an extracorporeal technique utilized for blood purification, it also complements convection diffusion solute removal. Since 1991 we had used purification techniques, over the years, new adsorption cartridges been developed, ones involving treatment inflammatory conditions, chronic uremic symptoms autoimmune diseases. HA130, HA230, HA330 (Jafron, Zhuhai...

Though artificial support systems for kidney failure have been widely available for the past several decades, it is only recently that they have become a promising treatment modality for liver failure. The various liver support systems include conventional dialysis, charcoal hemoperfusion, high volume plasma exchange, liver dialysis using sorbent technology, molecular readsorption recirculating...

An 82-year-old man with a mycotic aortic aneurysm of the distal arch underwent urgent surgery because of sepsis. The infected aortic arch was excised, replaced with a rifampicin-bonded prosthetic graft, and covered with omentum. Direct hemoperfusion using polymyxin B-immobilized fiber (PMX-DHP) was intraoperatively carried out in parallel with the cardiopulmonary circuit. Intraoperative PMX-DHP...

polymyxin B in 33 patients with primary and secondary rapidly progressive IP, a complex disease which has benefited from recent efforts to create a better definition [7] . At baseline, Hara et al.’s [6] patients were critically ill as indicated by median Pa O 2 /Fi O 2 ratio less than 150 mm Hg, mechanical ventilation requirement in 20 of them (17 tracheal intubations) and median SOFA score of ...

The application of carbonaceous adsorbents in medicine has old traditions. Still antique doctors used charcoal for treatment of wounds. To the beginning of ?? century the therapeutic use range of active carbons (? C) essentially has extended as an outside means (treatment of purulent wounds and ulcers, disinfecting in surgical and dental surgery practice), and internal adsorption preparation (e...