Wilson's disease (WD) is a rare inherited disorder of copper metabolism and the main manifestations are liver and brain disorders. Hemolytic anemia is an unusual complication of WD. We describe a 15-year-old girl who developed hemolytic anemia as the first manifestation of Wilson's disease. An Arg952Lys mutation was found in exon 12 of the ATP7B gene, which is uncommon among Chinese Han individ...

By ULFAR JONSSON, M.D., 0. C. HANSEN-PRUSS, M.D., AND R. W. RUNDLES, M.D. T HERE have been many reports in recent years of splenectomy for hemolytic anemia, thrombocytopenia, or pancytopenia resulting from vascular, infectious, or neoplastic involvement of the spleen.” 12, 13, 15 Hemolytic anemia has been observed in a few patients with leukemic splenomegaly) 6. 8. 13, 15 The leukemia has usual...

Auto-immune hemolytic anemia (AIHA) has an extensive differential diagnosis though Hodgkin’s lymphoma (HL) is not always an obvious diagnosis. AIHA can precede the diagnosis of HL for several years. In adults the association of AIHA and HL is more frequent in advanced stages of HL. Warm immune hemolytic anemia is mainly controlled with steroids and chemotherapy. We report a case of a patient wi...

As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or K(m), (decreased binding affinity) for a coenzyme, resulting in a lower rate of reaction. About 50 human genetic dis-eases due to defective enzymes can be remedied or ameliorated by the administration of high doses of the vitamin component of the corresponding coenzyme, whic...