Davie, Joseph M. (Indiana University, Bloomington), and Thomas D. Brock. Action of streptolysin S, the group D hemolysin, and phospholipase C on whole cells and spheroplasts. J. Bacteriol. 91:595-600. 1966.-The effect of streptolysin S, the group D hemolysin, and phospholipase C (the alpha toxin of Clostridium perfringens) on whole cells and spheroplasts or protoplasts of three strains of strep...

background: escherichia coli is the most causative agent of urinary tract infections (utis). apart from all human infectious diseases, uti have a high prevalence and in most cases, escherichia coli is a dominance bacterium which can cause pyelonephritis and cystitis. the aim of the study was to determine the occurrence of some virulence genes expressing fimbriae, production of hemolysin and aer...

Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus-associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin, and alpha-hemolysin - virulence factors necessary for bacterial replication in host tissues and, now, potential therap...

The histone-like protein H1 (H-NS) is an abundant structural component of the bacterial nucleoid and influences many cellular processes including recombination, transcription and transposition. Mutations in the hns gene encoding H-NS are highly pleiotropic, affecting the expression of many unrelated genes. We have studied the role of H-NS on the regulation of hemolysin gene expression in Serrat...

Polymorphonuclear leukocytes (PMN) have been identified as preferred target cells for Escherichia coli hemolysin in human blood (Bhakdi, S., Greulich, S., Muhly, M., Eberspächer, B., Becker, H., Thiele, A., and Hugo, F. (1989) J. Exp. Med. 169, 737-754). Leukotriene and 5-hydroxyeicosatetraenoic acid generation was investigated in human PMN challenged with E. coli hemolysin in the absence or pr...

Lipid bilayer experiments were performed in the presence of hemolysin of Escherichia coli. The toxin had a rather low activity in membranes formed of pure lipids, such as phosphatidylcholine or phosphatidylserine. In membranes from asolectin, a crude lipid mixture from soybean, hemolysin was able to increase the conductance by many orders of magnitude in a steep concentration-dependent fashion,...

Enterococci species are known commensals of the gastrointestinal flora; however, in recent years, they have emerged as important nosocomial pathogens that possess many virulence factors attributed to pathogenesis diseases caused by them. The study evaluated and compared isolated from fecal clinical samples. From obtained isolates, enterococcal isolates produced 35%, 20%, 50%, 23%, 13%, 13% gela...

38, 6th ASM Conference on Streptococcal Genetics, Ashville, NC, USA]. GBS β-h/c contributes to virulence in animal studies. When administered to neonatal rats via the pulmonary route, NH GBS mutants possess a 1000-fold greater LD50 than the wild-type parent strains, confirming a role in the pathogenesis of pneumonia and systemic spread [52]. In an adult mouse model of GBS arthritis, hemolysin e...