A case of successful gestation, delivery, and postpartum recovery in a woman with paroxysmal nocturnal hemoglobinuria (PNH) is presented. The rarity of pregnancy in patients with PNH and the nature and high rate of complications in such cases are discussed. Finally, suggestions are made for both antepartum and postpartum management of these unusual and complicated pregnancies.

Many antibodies that cause paroxysmal cold hemoglobinuria (Donath-Landstelner antibodies) appear to be directed against the blood group P antigen. We recently Identified this antigen as the glycosphingolipld globoside GaINAc(fl, 1-’3)Gal(a, 1-’4)Gal(fl, 1-’4)GlcCer, and we examined the reaction of four Donath-Landsteiner antibodies with anti-P specificity, and an anti-P acId autoagglutinin, wit...

abniornusity of the erythrocytes.’ Ins 1951 i’sIatthes et al.2 described the patchy appearanice of electrois nsicrosoopic preparat-iomss of hensolyzed erythrocytes from onie case of PNH. Receistly, however, Douglas ansd Eaton2 were unsable to timid sinssilar chiansges. 1 h presenst report fully confirms the result of Mat-t-hes et sl.2 Its view of the theoretic ansd practical insportansce of thi...

Over the past six years, a diverse group of stakeholders have put forth recommendations regarding the analytical validation of flow cytometric methods and described in detail the differences between cell-based and traditional soluble analyte assay validations. This manuscript is based on these general recommendations as well as the published experience of experts in the area of PNH testing. The...