نتایج جستجو برای: hemoglobin hb

تعداد نتایج: 66164  

Journal: :The American journal of clinical nutrition 2007
Kanokwan Sanchaisuriya Supan Fucharoen Thawalwong Ratanasiri Pattara Sanchaisuriya Goonnapa Fucharoen Ekkehart Dietz Frank P Schelp

BACKGROUND It is customary in Southeast Asia to treat pregnant anemic women with iron supplements, but anemia in this region may be complicated by thalassemia and hemoglobinopathies, which lead to an ineffective response. OBJECTIVE The aim was to determine whether routine iron supplementation during pregnancy in this area, which has a high prevalence of thalassemia and hemoglobinopathies, is ...

Journal: :Clinical chemistry 1999
F Cotton C Lin B Fontaine B Gulbis J Janssens F Vertongen

Hemoglobin A2 (Hb A2) and hemoglobin F (Hb F) are important analytes in the diagnosis and follow up of Hb diseases. We evaluated a new capillary zone electrophoresis (CZE) kit for Hb A2 and Hb F measurements. The imprecision ranged from 3% to 6% for Hb A2 and Hb F at physiological and pathological concentrations. The method compared well with cation-exchange HPLC for Hb A2 and Hb F and with ani...

Journal: :The Southeast Asian journal of tropical medicine and public health 2011
Somchai Sangkitporn Siripakorn K Sangkitporn Sansanee Tanjatham Boonnipa Suwannakan Suthatip Rithapirom Chonlada Yodtup Amara Yowang Sawitree Duangruang

Thalassemias and hemoglobinopathies are highly prevalent in Thailand and other Southeast Asian countries. Accurate and precise separation of hemoglobin types, together with reliable quantitation, are essential for differential diagnosis of these diseases. Presented in this study is a multicenter validation of a fully automated capillary electrophoresis (CE) method for hemoglobin separation and ...

2017
Sandeep Chakane Tiago Matos Karin Kettisen Leif Bulow

Hemoglobin (Hb) is well protected inside the red blood cells (RBCs). Upon hemolysis and when free in circulation, Hb can be involved in a range of radical generating reactions and may thereby attack several different biomolecules. In this study, we have examined the potential damaging effects of cell-free Hb on plasmid DNA (pDNA). Hb induced cleavage of supercoiled pDNA (sc pDNA) which was prop...

Journal: :The Journal of biological chemistry 1979
K Adachi T Asakura

A new turbidimetric method for the direct measurement of the solubility of oxy- and deoxyhemoglobins (Hb) in concentrated phosphate buffer has been established. The principle of the method is the formation of a homogeneous emulsion when hemoglobin is introduced in concentrated phosphate buffer. The solubility of the oxy and deoxy forms of Hb A, Hb S, Hb C, Hb F, and Hb CHarlem (beta 6Glu leads ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1976
D N Haney H F Bunn

To determine the mechanism for the formation of hemoglobin A1c (Hb A1c) in vivo, we incubated human hemoglobin with glucose and metabolites of glucose. [14C]Glucose-6-phosphate (G6P) reacted readily with deoxyhemoglobin, and formed a covalent linkage. The reaction rate was considerably reduced in the presence of carbon monoxide or 2,3-diphosphoglycerate (2,3-DPG). Purified G6P hemoglobin had a ...

Journal: :Turkish journal of haematology : official journal of Turkish Society of Haematology 2010
Aylin Köseler Hasan Koyuncu Onur Öztürk Anzel Bahadır Sanem Demirtepe Ayfer Atalay Erol Ömer Atalay

Hb Tunis [beta124(H2)Pro>Ser] was reported from Tunisia in 1988. This hemoglobin variant was detected by isoelectric focusing moving just ahead of Hb A. It cannot be identified by standard hemoglobin electrophoresis due to its similar mobility to Hb A. It has normal stability and oxygen affinity and does not produce any clinical symptoms. Here, we report a heterozygous Hb Tunis [beta124(H2)Pro>...

Journal: :The Journal of biological chemistry 1994
W Kaca R I Roth J Levin

Cell-free hemoglobin (Hb) is a purified preparation of human hemoglobin that is being developed as a resuscitation fluid. In vivo administration of hemoglobin has resulted in significant toxicity, due in part to contamination with bacterial endotoxin (lipopolysaccharide (LPS)). To better understand this toxicity, we have studied the interaction between Hb and LPS. Mixtures of each of three diff...

2017
Vikram M Raghunathan James N Butera Diana O Treaba

Hemoglobin (Hb) Sherwood Forest is a rare high-affinity hemoglobin first described in 1977, arising from an Arg to Thr substitution at codon 104 of the beta chain. This hemoglobin variant has been identified in few individuals and has been associated with a compensatory erythrocytosis in the homozygous state. Prior scarce case reports have noted that heterozygotes for this variant are phenotypi...

2007
Kanokwan Sanchaisuriya Supan Fucharoen Thawalwong Ratanasiri Pattara Sanchaisuriya Goonnapa Fucharoen Ekkehart Dietz Frank P Schelp

Background: It is customary in Southeast Asia to treat pregnant anemic women with iron supplements, but anemia in this region may be complicated by thalassemia and hemoglobinopathies, which lead to an ineffective response. Objective: The aim was to determine whether routine iron supplementation during pregnancy in this area, which has a high prevalence of thalassemia and hemoglobinopathies, is ...

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