background :identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. thus, low the mean corpuscular volume (mcv) and the mean corpuscular hemoglobin (mch) may consider as α-thalassemia key detection points. the present study aimed to determine the prevalence of microcytosis among neonates who born in ...

hemoglobin f (hbf, α 2 γ 2 ) is a major contributor to the clinical heterogeneity and ameliorating agent observed in patients with the β-globin disorders including β-thalassemia and sickle cell disease (scd). during fetal life, hbf is the major hemoglobin but is largely substituted by adult hemoglobin (hba, α 2 β 2 ) following a globin expression switch after birth. increased γ-globin expressio...

introduction: iron deficiency anemia (ida) is the most common form of anemia and one of the most important health problems. iron supplementation for high risk groups can prevent ida and its complications in the community. we need to have a holistic approach to control ida with minimum cost and complications. considering the high prevalence rate of ida in iran, assessment of the effects of micro...

background: efficient induction of fetal hemoglobin (hbf) is considered as an effective therapeutic approach in beta thalassemia. hbf inducer agents can induce the expression of γ-globin gene and produce high levels of hbf via different epigenetic and molecular mechanisms. thalidomide and sodium butyrate are known as hbf inducer drugs. material and methods : cd133 + stem cells were isolated fro...

background: high maternal hemoglobin (hb) concentration was considered a risk factor for the developing of pregnancy hypertension. the purpose of this study was to determine whether high maternal hb concentration in first trimesters associated with pregnancy induced hypertension in iranian nulliparous women. methods: this study was carried out in teaching hospital in sari, iran. samples were ob...

adverse outcomes of pregnancy increase among women with high density of hemoglobin. this study evaluates the effects of iron supplementation on serum copper level in pregnant women with hemoglobin higher than 13.2 g/dl. sixty two pregnant women with hemoglobin >13.2 g/dl and normal serum copper levels in their 13-18 weeks of gestation were randomized into case and control groups. from 20 th wee...

The physicochemical and biochemical properties of hemoglobin associated with haptoglobin were compared with those of hemoglobin bour,d by antihemoglobin antibody. The mechanism of enhanced peroxidase activity of hemoglobin bound by haptoglobin was concluded not to be activation but stabilization of hemoglobin at acidic pH by haptoglobin. Haptoglobin protects hemoglobin from denaturation by acid...