Hematopoietic stem cell transplantation (HSCT) is a life-saving therapy for various hematologic disorders. Due to the bone marrow suppression and its long recovery period, secondary infections, like cytomegalovirus (CMV), Epstein-Bar virus (EBV), adenovirus (AdV), are leading causes of morbidity mortality in HSCT cases. Drug resistance antiviral pharmacotherapies makes researchers develop adopt...

Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become a valuable strategy for some intractable diseases, a number of problems remain to be resolved. We have developed a new HSCT method, HSCT + thymus transplantation (TT) from the same donor, which induces elevated T cell function with mild graft-versus-host disease (GVHD) in comparison to conventional HSCT alone and...

background: antibiotic prophylaxis is usually used in allogenic stem cell transplantation, but its use in autologous stem cell transplantation (asct) is controversial. we evaluated the efficacy of ciprofloxacin prophylaxis in asct. materials and methods: to identify the efficacy of ciprofloxacin on the incidence of neutropenic fever and its complications, 72 patients had been admitted to talegh...

introduction: severe acquired aplastic anemia (saa) is a rare disease and matched related hematopoietic stem cell transplantation (hsct) is the treatment of choice especially in pediatric patients. immunosuppressive therapy is the alternative treatment in patients who do not have a donor. we retrospectively analyzed patients who received allogeneic hsct at our institution. methods: between 1991...

Aplastic anaemia is a severe haematological disorder characterized by an inadequate number of hematopoietic stem cells, resulting in pancytopenia, formed hypocellular bone marrow. Disorders this nature are widely treated with haematopoietic cell transplantation (HSCT). A potential chronic complication following (HSCT) the growth secondary malignancies. Notably, patients suffering from graft ver...

Successful allogeneic hematopoietic stem cell transplantation (HSCT) depends not only on good HLA match but also on T-cell mediated graft-versus-leukemia (GvL) effect. Natural killer (NK) cells are able to kill malignant cells by receiving activation signal from the killer-cell immunoglobulin-like receptors (KIR) recognizing HLA molecules on a cancer cell. It has been recently reported that the...

GlobalUseof Peripheral BloodvsBoneMarrow as Sourceof StemCells forAllogeneic Transplantation inPatientsWithBoneMarrowFailure Hematopoietic stemcell transplantation (HSCT) is a therapeutic option formany patients with bonemarrow failure.1 Bone marrowwas initially the only stem cell source available until the 1990swhen peripheral blood stem cells (PBSCs) and cord blood began to be used. Currently...

BACKGROUND Some uncommon lymphoproliferative and histiocytic disorders may present with an aggressive course and require hematopoietic stem cell transplantation (HSCT) as part of the therapeutic approach. METHODS Published research on the use of HSCT for the treatment of these disorders was reviewed and summarized. RESULTS Allogeneic HSCT may be indicated in patients with blastic plasmacyto...

IMPORTANCE Stiff person syndrome (SPS) is a rare neurological disease causing significant functional disability for patients and presenting a therapeutic challenge for clinicians. Autologous hematopoietic stem cell transplantation (auto-HSCT) has been used successfully to remit autoimmune-mediated neurological diseases. We report 2 cases of severe SPS treated with auto-HSCT, a novel therapy for...

Background: There is a worldwide effort to present novel approaches for the development of tolerance-induction treatments in regenerative medicine, after years of investigation in clinical transplantation. Particularly, novel approaches are based on controlling the immune response, including the application of biomaterials or imitation of antigen-specific peripheral tolerance in either solid-or...