E. Silva1, Z. Gatalica2, S. Vranic3, G. Basu4, S.K. Reddy5, A. Voss6 Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA Molecular Diagnostics, Caris Life Sciences, Phoenix, AZ, USA Pathology, Clinical Center, University of Sarajevo, Sarajevo, BOSNIA AND HERZEGOVINA Molecular Diagnostics, Caris Life Sciences, Phoenix, AZ, USA Hematology and Oncology, Los Alamitos Hemato...

Homozygous knockout of p53 in mice leads to early mortality from lymphoma, with almost complete penetrance, thus hampering studies of other tumor histotypes related to p53 alterations. To avoid lymphoma development, we crossed p53 knockout mice (BALB-p53 mice) with alymphocytic BALB/c Rag2-/-;Il2rg-/- (RGKO) mice. We compared the tumor spectrum of homozygous (BALB-p53-/-) and heterozygous (BALB...

OBJECTIVE To investigate associations between age at gonadectomy and estimated risk or age at diagnosis of neoplastic and behavioral disorders in Vizslas. DESIGN Retrospective cohort study. ANIMALS 2,505 Vizslas born between 1992 and 2008. PROCEDURES Data on demographics, gonadectomy status, and age at diagnosis of disease or disorder were obtained with an anonymous online survey and anal...

Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA damage in vivo in liver and kidney of rats. Both the commercial and repurified pro...

1. Kanis JA. Pathophysiology and treatment of Paget’s disease of bone, 2nd edn. London: Martin Dunitz, 1998. 2. Moore TE, King AR, Kathol MH, El-Khoury GY, Palmer R, Downey PR. Sarcoma in Paget’s disease of bone: clinical, radiological and pathological features in 22 cases. Am J Radiol 1991;156:1199–203. 3. Chen KTK. Hemangiosarcoma complicating Paget’s disease of the bone. J Surg Oncol 1985;28...

This study demonstrated magnetic resonance imaging (MRI) and computed tomography for large-sized splenic hemangiosarcoma. Radiography and ultrasonography revealed the presence of a large-sized soft-tissue mass in the cranial abdomen. Computed tomography showed hypoattenuating mass. The mass was located in contact with liver, spleen and stomach, and the origin of the mass remained ambiguous. The...