Title of dissertation: COMPILER-BASED PRE-EXECUTION Dongkeun Kim, Doctor of Philosophy, 2004 Dissertation directed by: Professor Donald Yeung Department of Electrical and Computer Engineering Pre-execution is a novel latency-tolerance technique where one or more helper threads run in front of the main computation and trigger long-latency delinquent events early so that the main thread makes for...

We have described a model system in which helper T cells are required to mount a primary antiviral cytolytic T lymphocyte response. The radioresistant helper cell can be found in the spleens of mice that have been immunized subcutaneously with influenza viruses 6-8 d previously. These helper cells appear to be type specific but cross-reactive among the subtypes of influenza A viruses. The pheno...

objective(s): adeno-associated virus type 2 (aav2) vectors are widely used for both experimental and clinical gene therapy. a recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. in this study, a fast and simple method is presented to generate aav2 vector helper plasmids encodin...

Locally repairable codes (LRCs) are ingeniously designed distributed storage codes with a (usually small) bounded number of helper nodes participating in repair. Since most existing LRCs assume exact repair and allow full exchange of the stored data (β = α), they can be viewed as a generalization of the traditional erasure codes (ECs) with a much desired feature of local repair. However, it als...

ESP-1 virus provides a helper function to defective Friend spleen focus-forming virus (SFFV). This helper activity is demonstrable only in B-type mice (Fv-lbb) under conditions in which the N-tropic lymphatic leukemia-inducing virus contained in the Friend virus complex is inhibited. ESP-1 virus therefore expresses a B-tropic host range in vivo with respect to its ability to provide a helper fu...

The humoral immune response to heterologous erythrocytes requires the cooperation of B lymphocytes and helper T cells. The production of anti-sheep erythrocytes (SRBC) 1 IgG is almost wholly dependent on the activity of T help (reviewed in 1). Helper T cells that recognize the carrier portion of an immunogen have been known for some time (2). More recently evidence has accumulated that other he...

Priming of BALB/c mice with phosphorylcholine-hemocyanin (PC-Hy) induces T helper cells that are detected in splenic fragment cultures responding to immunization with trinitrophenylated PC-binding myeloma proteins, TEPC 15 (TNP-T15) and MOPC 167 (TNP-M167). Trinitrophenylation did not alter the binding site, idiotype, or isotype of the antibodies as demonstrated by binding studies. To assay idi...

Retroviral vector producer cells (VPC) have been considered genetically stable. A clonal cell population exhibiting a uniform vector integration pattern is used for sustained vector production. Here, we observed that the vector copy number is increased and varied in a population of established LTKOSN.2 VPC. Among five subclones of LTKOSN.2 VPC, the vector copy number ranged from 1 to approximat...

Background Cancers produce soluble and cell-associated molecules that can suppress or alter antitumor immunity. Preclinical studies suggest the disease burden may alter the cytokine profile of helper T cell responses to cancer antigens. We studied cytokine production by helper T cells responding to vaccination with 6 melanoma helper peptides (6MHP) in blood and lymph nodes. We describe here the...