Human ferritin platforms containing Ru( ii )-polypyridyl-based photosensitizers effectively target cancer cells and provide cytotoxic effects upon light-activation.

Members of the genus Lathyrus are used as food and as traditional medicines. In order to find new sources of biologically-active compounds, chemical and biological profiles of two Lathyrus species (L. czeczottianus and L. nissolia) were investigated. Chemical profiles were evaluated by HPLC-ESI-MSn, as well as by their total phenolic and flavonoid contents. In addition, antioxidant, enzyme inhi...

Myricetin (Myr) is a f lavonoid that exerts anti-arrhythmic effects. However, its potential effects on ion channels have remained elusive. The aim of the present study was to investigate the effects of Myr on Kv1.5 channels in HEK293 cells. The current of Kv1.5 channels (Ikur) in HEK293 cells was recorded using the whole-cell patch-clamp technique and the expression of the Kv1.5 protein was mea...

the present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of phlomis kurdica. the antioxidant and anti-tyrosinase activity of meoh extract from p. kurdica (mpk) were examined by dpph radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. furthermore, the effect of mpk on the melanin content, cellular tyrosinase ...

BACKGROUND Extracellular translationally controlled tumor protein (TCTP) is known to play a role in human allergic responses. TCTP has been identified outside of macrophages, in activated mononuclear cells, and in biological fluids from allergic patients. Even TCTP devoid of signal sequences, is secreted to extracellular environment by an yet undefined mechanism. This study is aimed at understa...

background: bacterial dna has immunostimulatory effects on different types of immune cells such as dendritic cells (dcs). application of dcs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. objectives: to investigate the effect of tumor antigen pulsed dcs in the presence of cpg-1826 in treatment of a murine model of cancer. methods: ...

objective: hypoxia-inducible factor (hif)-1 plays an essential role in the body’s response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses. increased levels of hif-1α are associated with increased proliferation and more aggressive breast tumor development. lactobacilli have...

The medicinal plants have been used since ancient times and are still utilized by the majority of the population. Hence, it is essential to investigate the cytotoxic and genotoxic effects of these plants. The aim of this study was to evaluate the toxic effects of fennel seeds decoctions, traditionally used in Iran as an herbal remedy.  The cytotoxicity was tested in vitro using Allium cepa L. r...