نتایج جستجو برای: heart protection
تعداد نتایج: 562768 فیلتر نتایج به سال:
BACKGROUND Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann-Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces the risk of coronary heart disease is not known. Human mutations that inactivate a gene encoding a drug target can mimic the action of an inhibitory drug and thus can be used to infer potential ...
CARDIORENAL AXIS Normally, the cross-talk between the heart and the kidneys occurs through atrial-renal reflexes3, which contribute to maintaining the total body volume in the normal range. In a nonfailing heart, any increase in atrial pressure diminishes the arginine vasopressin release (AVP)4 through the Henry Gauer Reflex, decreases renal sympathetic tone5, and increases the atrial natriuret...
Correspondence: Mohamed S. A. Mohamed, MBBCh, MSc, MD. Thoracic Transplantation Department, University Clinic Essen, Germany, Hufeland Straße 55. D-45147 Essen. Email:[email protected] Ischemic preconditioning is a technique where prior application of repeated short cycles of ischemia and reperfusion would be able to attenuate the severity of the subsequent ischemic reperfusion injur...
Background—Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann–Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces the risk of coronary heart disease is not known. Human mutations that inactivate a gene encoding a drug target can mimic the action of an inhibitory drug and thus can be used to infer potential ...
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Research has shown that the majority of the cardiometabolic alterations associated with an increased risk of CVD (e.g., insulin resistance/type 2 diabetes, abdominal obesity, dyslipidemia, hypertension, and inflammation) can be prevented, and even reversed, with the implementation of healthier die...
Background & Aims: Doxorubicin (DOX) is an anthracycline antibiotic that is widely used as an anticancer agent. However, the clinical use of DOX is limited due to its toxic side effects upon non-target tissues. The aim of this study was to investigate the impact of 6 weeks of aerobic training on dox-induced toxicity in rat tissues (heart and liver). Materials & Methods: This study was conduc...
Background—Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann–Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces the risk of coronary heart disease is not known. Human mutations that inactivate a gene encoding a drug target can mimic the action of an inhibitory drug and thus can be used to infer potential ...
Intralipid as a first safe fat emulsion for human use has been shown to be cardio protective in some recent studies. This is a brief review with the main focus on recent studies about intralipids and their role in the heart protection. Intralipids as a source of calories have been applied for several years to cure patients. However, there are rare reports in the case of rescuing effect in many ...
Extracellular ATP plays an important role in ischemic preconditioning (IPC) through the activation of P(2y) purinoceptors. This study examined whether ATP-stimulated P(2y) purinoceptors are coupled to pertussis toxin (PTX)-insensitive G protein and whether activation of this pathway enhances myocardial protection afforded by IPC. The rat was treated with PTX for 48 h, and the heart was then iso...
The evolution of myocardial protection techniques has been both the source of milestone advancements and controversial debate in cardiac surgery. Our institution has modified a low-prime cardioplegia system (CPS) and adopted a single-dose cardioplegia solution (del Nido cardioplegia) for our congenital heart disease population. The goal of this article is to describe our CPS and outline our myo...
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