The KEYNOTE-181 study has demonstrated the prolonged survival benefits of pembrolizumab compared with chemotherapy as second-line treatment among Chinese patients ESCC. This aimed to assess cost-effectiveness versus advanced ESCC who failed first-line treatment. We developed a Markov model simulate progression through three health status (progression-free survival, progressed disease, and death...

BACKGROUND An increasing amount of studies report mapping algorithms which predict EQ-5 D utility values using disease specific non-preference-based measures. Yet many mapping algorithms have been found to systematically overpredict EQ-5 D utility values for patients in poor health. Currently there are no guidelines on how to deal with this problem. This paper is concerned with the question of ...

BACKGROUND Utility indices are used in cost-effectiveness analyses as a measure of quality of life reflecting the patient's preference for a given health state on a scale anchored at 0 (corresponding to death) to 1 (perfect health). It is uncertain which utility instruments are most suitable for application in patients with the obstructive sleep apnea syndrome (OSA). OBJECTIVES To compare uti...

conclusions oral health behavior-related factors can influence patients’ periodontal status and oral hygiene levels. results in total, 50.8% of participants had cpi 2, and the average of sohi was 1.97 ± 0.7 (fair to poor). among lifestyle variables, smoking and physical activity each had a significant relationship with periodontal health (p = 0.0001 and p = 0.001, respectively). there were also...

Copyright © 2015 by Journal of Korean Academy of Oral Health This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives: The purpose of th...

INTRODUCTION We prospectively evaluated health-related quality of life (HRQoL) through the gastrointestinal quality of life index (GIQLI) as a system to prioritize patients on the waiting list for laparoscopic cholecystectomy (LC) and its correlation with a linear prioritization system developed in the General and Gastrointestinal Surgery Institute of Clínica Quirón in Valencia. MATERIAL AND ...

PURPOSE To estimate health status utility values in patients with age-related macular degeneration (ARMD) associated with visual impairments, by using preference-based measures of health. METHOD This was a cross-sectional study involving patients with unilateral or bilateral ARMD who attended a large teaching hospital. Patients underwent visual tests (near and distant visual acuity [VA] and c...

BACKGROUND Utility estimates are important health outcomes for economic evaluation of care and treatment interventions for patients with HIV/AIDS. We conducted a systematic review and meta-analysis of utility measurements to examine the performance of preference-based instruments, estimate health utility of patients with HIV/AIDS by disease stages, and investigate changes in their health utilit...

OBJECTIVE This prospective study examined the convergent validity and responsiveness of the EuroQoL-5 Dimensions Health Questionnaire (EQ-5D) utility weights in stroke survivors at the subacute stage. METHODS Repeated assessments were conducted in rehabilitation wards of a medical centre. A study cohort was recruited from inpatients (n = 478). A total of 342 participants (71.5%) completed 2 a...

The 15D is a generic, 15-dimensional, standardised, self-administered measure of health-related quality of life (HRQOL), that can be used as a profile and single index score measure. This paper introduces alternative valuation models based on the multi-attribute utility theory for generating the single index scores, and examines their feasibility, reliability and validity by using several data ...