BACKGROUND Hepatocellular carcinoma is a highly progressive cancer in the case of late diagnosis which is frequently associated with HBV and HCV viral infections. OBJECTIVES To identify differentially expressed serum proteins among three main stages of HCV infection and healthy individuals, and their comparisons with sera from patients with the same stage of HBV infection. PATIENTS AND METH...

Dear Editor, Chronic carriers of hepatitis infection are living throughout the world mostly in the South East of Asia. Recent studies have shown that some HBsAg negative individuals may develop some sort of chronic hepatitis B which is detectable employing some new laboratory diagnosis techniques such as molecular tests. In human during decades, HBV had many mutations by which this virus has be...

Hepatitis B virus (HBV) infection is a global problem and a major risk factor for hepatocellular carcinoma (HCC). microRNAs (miRNAs) comprise a group of small noncoding RNAs regulating gene expression at the posttranslational level, thereby participating in fundamental biological processes, including cell proliferation, differentiation, and apoptosis. In this review, we summarize the roles of m...

Hepatitis B surface antigen (HBsAg) is considered the best marker for the diagnosis of hepatitis B virus (HBV) infection. Mutations of the s gene involving amino acid substitutions within the a determinant could affect the sensitivity of diagnostic tests. In the present study, HBsAg mutants were detected in 3 immunocompromised patients, previously found to be HBsAg negative and anti-HBs positiv...

BACKGROUND WHO developed a global strategy to eliminate hepatitis B by 2030 and set target to treat 80% of people with chronic hepatitis B virus (HBV) infection eligible for antiviral treatment. As a first step to achieve this goal, it is essential to conduct a situation analysis that is fundamental to designing national hepatitis plans. We therefore estimated the prevalence of chronic HBV infe...

Background & Aims HBV genotype G (HBV/G) is mainly found in co-infections with other genotypes and was identified as an independent risk factor for liver fibrosis. This study aimed to analyse the prevalence of HBV/G healthy European carriers characterize crosstalk genotypes. Methods A total 560 were tested via HBV/G-specific PCR co-infections. Quasispecies distribution analysed deep sequencing,...

diagnosis of hepatitis b is routinely based on of serological assay of hepatitis b surface antigen (hbsag). occult hepatitis b virus (hbv) infection is generally defined as the detection of hbv -dna in the serum or tissues of subjects who have negative test for hbsag. transmission of hbv infection has been documented from hbsag negative, anti-hbc positive blood and organ donors. the aim of this...

Sexual dimorphism in infectious diseases refers to the different infection susceptibilities and outcomes between males females, has been described for many pathogens, including hepatitis B virus (HBV). HBV is a substantial global health problem, with close 300 million people chronically infected, accounting deaths each year, an urgent need enhanced interventions support progress towards ...

hepatitis b is the most common cause of acute and chronic viral hepatitis in iran. it is the etiology of 70% of end-stage liver disease and hepatocellular carcinoma in the country. before the universal neonatal vaccination in iran (1992), the contact rate with hbv was about 30% and the hbs ag+ rate was about 3%. in 2009 the contact rate has declined to 18% and hbsag+ rate decreased to 2%. the e...