BACKGROUND The coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in patients with chronic hepatitis B virus (HBV) infection has been explained by the presence of viral escape mutants. Yet, no systematic analysis of such patients has been performed. We analyzed both the HBV strains and the nature of anti-HBs in such patients. METHODS Four hundred eleven pati...

Papaevangelou, G., Kremastinou, T., Prevedourakis, C., and Kaskarelis, D. (1974). Archives of Disease in Childhood, 49, 936. Hepatitis B antigen and antibody in maternal blood, cord blood, and amniotic fluid. Transplacental transmission of hepatitis B virus from hepatitis B antigen carrier mothers was investigated by studying the presence of the antigen and its antibody in maternal blood, umbil...

The use of molecules that represent single, defined epitopes able to substitute for antigen (i.e. surrogate antigens) offers considerable advantages over the use of native antigen for the precise manipulation of the immune response. We have investigated the immunochemical characteristics of two types of surrogate hepatitis B surface antigen (HBsAg) epitopes: (a) linear and cyclical synthetic pe...

Hepatitis B surface antigen (HBsAg) and antibodies to both the surface and core antigens of the hepatitis B virus (anti-HBs and anti-HBc) have been studied in 64 consecutive cases of fulminant hepatitis. HBsAg was detected by counterelectrophoresis in 23 (35-9 %) but by radioimmunoassay in 38 (59-3 %). Anti-HBs was detected by passive haemagglutination in 26 (40-6 %), coexisting HBsAg and anti-...

Submit Manuscript | http://medcraveonline.com Abbreviations: HBV: Hepatitis B Virus; HBs Ag: Hepatitis B Surface Antigen; HBe Ag: Hepatitis B e Antigen; anti-HBe Ab: Hepatitis B e Antibodies; HCC: Hepatocellular Carcinoma; HDV: Hepatits Delta Virus; GGT: Gamma-Glutamyl Transpeptidase; ALP: Alkaline Phosphatase; ALT: Alanine Aminotransferase; AST: Aspartate Aminotransferase; AFP: Alpha Foeto-Pro...

BACKGROUND The interleukin (IL)18 rs360719 CC genotype is associated with the development of antibodies to hepatitis B virus surface antigen (anti-HBs) in hemodialysis (HD) patients. IL18 shares biological properties with IL12 in promoting the T-hepler 1 (Th1) system. We studied whether polymorphisms in the IL12A 3` untranslated region (UTR) and IL12B 3`UTR may contribute to anti-HBs developmen...

Objectives: Hepatitis B virus infection and associated diseases are a major public health problem. This study was planned to find out the persistence of antibody against hepatitis B surface antigen in Iranian vaccinated children after five years. Methodology: Anti-HBs titers in a group of healthy good – responder children who were vaccinated with Cuban hepatitis B vaccine in infancy were measur...

INTRODUCTION Vaccination is the main tool for preventing hepatitis B virus (HBV) infection; however, following the completion of the vaccination series, the concentrations of anti-HBs can decline over the years and reach levels less than 10mIU/mL. The persistence of protection in these individuals is still unknown. The present study aimed to determine the anti-HBs antibody levels among children...