One of the most exciting avenues of translational research today is determining how to program ab T cells of the immune system to treat diseases such as cancer. The main function of T cells is the surveillance of unhealthy cells throughout the body. Because of their specificity, function, and lasting memory, T cells can contribute to the prevention and treatment of many diseases. Two approaches...

Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific sk...