Harlequin ichthyosis is a very rare condition that affects the skin of newborns. It is associated with poor barrier function of the skin leading to dehydration and leaves newborns prone to infections. It is due to mutations in adenosine triphosphate binding cassette A12 gene transmitted as an autosomal recessive disorder. The prognosis is very poor in these cases. Here, we report one such rare ...

A 63-year-old male experienced 3 years of excruciating, right retro-orbital, 15–90 minute headaches occurring 1 to 3 times daily associated with ipsilateral lacrimation, ptosis, and facial congestion. The episodes began after a complicated right root canal procedure. He also reported separate episodes of distinct left sided facial flushing triggered by exertion as evidenced by a photo that he p...

We report the development of Harlequin Syndrome following thoracic epidural placement in a pediatric patient. Unilateral facial flushing with contralateral pallor and anhidrosis is the clinical presentation. This syndrome is typically benign. When related to regional anesthesia, treatment involves reducing the local anesthetic infusion or stopping it altogether.