1Institute of Hematology, University of Perugia, Perugia, Italy; 2Hematology, University of Siena and Azienda Ospedaliera Universitaria Senese, Siena, Italy; 3Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Section, University of Padua, Padua, Italy; 4Department of Medicine, Hematology Section, University of Verona, Verona, Italy; 5Department of Pathology, C...

BACKGROUND Distinction between mature B-cell neoplasms can be difficult due to overlapping of immunologic features and clinical manifestations. This study investigated whether quantifying mean fluorescence intensity of four monoclonal antibodies in a flow cytometry panel is useful for the differential diagnosis and characterization of these disorders. METHODS The expressions of CD52, CD200, C...

The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF ...