Alopecia areata is considered to be a cell-mediated autoimmune disease, in which autoreactive cytotoxic T cells recognize melanocyte-associated proteins such as tyrosinase. This review discusses recent advances in the understanding of the pathogenesis of alopecia areata, focusing on immunobiology and hormonal aspects of hair follicles (HFs). The HF is a unique "miniorgan" with its own immune an...

BACKGROUND Pilonidal disease is foreign body reactions accompanied by chronic inflammation that most commonly arises in the hair follicles of the natal cleft or other hair-bearing areas. Today, surgical intervention remains the treatment of choice. But surgical treatment is an invasive method with a high failure rate and recurrence. OBJECTIVES The authors' objective was to assess the efficacy...

OBJECTIVES Hair coloring products are widely used and contain components that are mutagenic and carcinogenic. An association between occupational exposure to hair coloring products and hematopoietic cancers has been reported, but the risk for these cancers among users has not been carefully evaluated. METHODS We conducted a population-based, case-control study with telephone interviews from 3...

BACKGROUND Alopecia areata is a common cause of hair loss seen in 3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the general US population. The pathology of the disease remains poorly understood. Hair loss in alopecia areata can range from a single patch to 100% loss of body hair. When hair regrowth occurs in alopecia areata, the new hair may demonstrate pigment alterations, but...

Chikungunya (CHIK) is a disease caused by a mosquito-borne alphavirus (the mosquitos Aedes aegypti or Aedes albopictus). The chikungunya virus (CHIKV) is present all over the world. Several clinical symptoms have been associated with CHIK including hair loss. The aim of this review is to present some symptoms related to CHIK, tissues and organs targeted by the CHIKV and to suggest how the infec...

The hair of all mammals consists of terminally differentiated cells that undergo a specialized form of apoptosis called cornification. While DNA is destroyed during cornification, the extent to which RNA is lost is unknown. Here we find that multiple types of RNA are incompletely degraded after hair shaft formation in both mouse and human. Notably, mRNAs and short regulatory microRNAs (miRNAs) ...

Hair is one of the essential characteristic features which not only adds beauty to person but also helps maintain normal physiological functions, especially by excreting sweat through Lomakupa, considered roots Swedavaha Strotas. It in thermoregulation, protection etc. Pitruja Bhava and Mala Asthidhatu. Depending upon conditions, can assess some underlying pathological status body. Aims & O...

background and objective: rosacea is a common and ill-defined disease and demodex folliculorum has been reported in rosacea in a number of clinical studies. since demodex mite is present in many healthy individuals, the mite may have a pathogenic role only when it is present in high densities. therefore, in this study, the possible role of demodex folliculorum and the importance of mite density...

Trichothiodystrophy (TTD) is a rare, autosomal recessive disease, characterised by brittle, sulfur deficient hair and multisystem abnormalities. A systematic literature review identified 112 patients ranging from 12 weeks to 47 years of age (median 6 years). In addition to hair abnormalities, common features reported were developmental delay/intellectual impairment (86%), short stature (73%), i...