PURPOSE Our aim was to assess the validity of the ICD-10 code for splenomegaly in the Danish National Registry of Patients (DNRP), as well as to investigate which underlying diseases explained the observed splenomegaly. BACKGROUND Splenomegaly is a common finding in patients referred to an internal medical department and can be caused by a large spectrum of diseases, including haematological ...

INTRODUCTION Immunotherapy with the anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody ipilimumab has been shown to improve overall survival in previously treated and treatment-naïve patients with unresectable stage III or IV melanoma. Consistent with its proposed immunomodulating mechanism of action, the most common toxicities associated with ipilimumab therapy are immune-related in nat...

How to cite this article: Groenewald AJ, Walsh CM, Van Wyk HJ, Van Zyl S, Van der Merwe LJ. Staging and haematological abnormalities of HIV-infected persons in Mangaung in the Free State Province, South Africa. Afr J Prm Health Care Fam Med. 2012;4(1), Art. #462, 5 pages. http://dx.doi.org/10.4102/ phcfm.v4i1.462 Background: The prevalence of HIV in specific areas of South Africa and its impact...

A sudden increase in severe influenza has been registered in the Czech Republic since the end of 2012, with 264 cases requiring intensive care, including 51 deaths. Most patients had at least one risk factor. Severe influenza in patients with obesity, smoking and/or haematological disorders including haematological cancers was more frequent than in the pre-pandemic period. The seasonal influenz...

Background: As to whether the presence of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency ameliorates or worsens sickle cell disease (SCD) is still not clear. Aim and Objectives: This study was therefore aimed at investigating whether the presence of G6PD deficiency among SCD subjects (HbSS and HbSC) would have any significant impact on the severity of crisis and haematological indices. Sub...

This paper describes the design and the implementation of a web-enabled integrated haematological system, named e-HS. The proposed system runs on a set of distributed network nodes providing useful haematological services. These services include patient-oriented data management, digitized histopathological slides (DHS) acquisition, teleconsulting facilities, etc. The objective of e-HS is to sup...

OBJECTIVE To establish the bone marrow examination findings and determine the indication for bone marrow examination. DESIGN A retrospective audit. SETTING Aga Khan University Hospital, Nairobi. SUBJECTS All bone marrow aspirates done at Aga Khan University for the period comprising February 2003 to February 2006 were retrieved and analysed. RESULTS A total of 356 patient's case histori...

Increased knowledge of the immunophenotypic, cytogenetic and molecular heterogeneity of haematological diseases has challenged the traditional approach to disease classification based on morphology. In the current WHO classification, an integrated approach combining clinical details, morphology, immunophenotyping and genetic features is used for the diagnosis of haematological malignancies. An ...

OBJECTIVES Current UK health policy promotes enabling people to die in a place they choose, which for most is home. Despite this, patients with haematological malignancies (leukaemias, lymphomas and myeloma) are more likely to die in hospital than those with other cancers, and this is often considered a reflection of poor quality end-of-life care. This study aimed to explore the experiences of ...