Hypericum perforatum is known to have diverse medicinal uses for centuries. The antidepressant activity of Hypericum perforatum is widely accepted and proved in both animal and clinical studies. Present study was undertaken to investigate the effect of Hypericum perforatum in a battery of animal models for metabolic disorder. Hypericum is tested for hypolipidemic activity in normal rats, antiob...

the genus hypericum is one of the most important medicinal plants that contain 17 species in iran, three of them are endemics. this paper reports the essential oil composition of six hypericum species from iran. the essential oil analysis of a number of the studied plants has already been reported but their report from iran may be valuable for scientists.  samples collected between june and aug...

Hypericum perforatum, known as St. John's Wort and most used ethnaformacolgically, belongs to the Hypericaceae family. In this work, we aimed evaluate antioxidant, antimicrobial, DNA protective activities, enzyme inhibitor properties of domestic import H. perforatum aqueous extracts. The total phenolic flavonoid contents were also determined for both samples. Results exhibited a high content Do...

Following preparative isolation and purification by high-speed counter-current chromatography (HSCCC), the collected fractions were generally analyzed by high-performance liquid chromatography (HPLC) to determine the relative purities of each fraction. Our paper reports for the first time a preparative isolation-purity detection hyphenated system: online coupling of HSCCC with high-performance ...

Biological control agents may have unintended effects on native biota, particularly species that are closely related to the target invader. Here, we explored how Chrysolina quadrigemina, a beetle introduced to control the invasive weed Hypericum perforatum, impacts native H. punctatum in Tompkins County, New York, USA. Using a suite of complementary field surveys and experimental manipulations,...

The primary goal of the present study aimed to evaluate the prophylactic effect of Hypericum Perforatum L. extract on memory dysfunction induced by scopolamine in adult male albino rats (Rattus norvegicus Berkenout). Rats administered daily P.O Hypericum Perforatum L. extract (350 mg/kg) for two, four, eight weeks and the group of rats at the end of each interval intraperitoneally administered ...

Hypericum perforatum L. is a popular and widespread medicinal plant used in wide range of therapy, including gastrointestinal diseases, heart skin-related diseases. The rapid development nanotechnology its applications pharmacology have enabled the controlled release drugs bioactive components. This study aimed to investigate liposomal formulation for enriched with methanol ethanol extract H. p...

BACKGROUND Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis. METHODS Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was admi...

background & aim: st john's wort (hypericum perforatum l.) contains hypericin and hyperforin as the main components of the extract that binds with gaba and sigma opioid receptors. this herb has many pharmacological effects, including analgesic, sedative, soothing, antispasmodic, anticonvulsant, anti-depressant, and anti-bacteria. in this study examined the effect of two concentrations of hy...