The genetic transmission of the capacity to develop an immune response to hapten-polylysine conjugates was studied in guinea pigs. 82 per cent of the 22 offspring of 8 pairs of responder (guinea pigs which are capable of an immune response) parents were also responders, whereas, none of the 26 offspring of 9 pairs of non-responder parents were responders. None of 11 strain 13 guinea pigs and 10...

1. Because it has been shown that a majority of alcoholics are subclinically scorbutic, the metabolism of ethanol was studied in subclinically-scorbutic guinea-pigs. 2. Hepatic alcohol dehydrogenase activity was raised maximally by ethanol within 2 days. 3. In twenty-three subclinically-scorbutic guinea-pigs fed ethanol for 2 weeks, the alcohol dehydrogenase activity (& SD) was 11.5 +_ 1.2 unit...

previous studies have indicated relaxant, inhibitory effect on histamine (h1) and muscarinic receptors, and stimulatory effect on β-drenoceptor of crocus sativus on guinea pig tracheal chains. in the present study, the effect of the extract of c. sativus and one of its constituents, safranal, on the inflammatory changes of sensitized guinea pigs was examined. eight groups of sensitized guinea p...

A strain of choriomeningitis virus which was highly virulent for guinea pigs, as isolated from a naturally infected white mouse, has been markedly attenuated for guinea pigs by serial intracerebral passage through white mice. The change of virulence occurred before the 8th serial passage. The modified virus as a rule produces fever in guinea pigs but no other symptoms, and the infection is foll...

Objective In previous studies, the relaxant, anticholinergic (functional antagonism), antihistaminic and its stimulatory effects on b-adrenoceptors of Nigella sativa have been demonstrated on guinea pig tracheal chains. In the present study, the relaxant effects of hydro-ethanolic, macerated aqueous (MA) and lipid-free macerated aqueous (LFMA) extract of Nigella sativa on tracheal chains of gu...

The impact of vaccination with plasmid DNA encoding full-length glycoprotein D (gD) from herpes simplex virus (HSV) type 2 (gD2), secreted gD2, or cytosolic gD2 was evaluated in mice and guinea pigs. Immunization with plasmids encoding full-length gD2 or secreted gD2 produced high antibody levels, whereas immunization with DNA encoding cytosolic gD2 resulted in significantly lower antibody tite...

In this research, anatomical descriptions of the structure of the temporal bone and auditory ossicles have been performed based on dissection of ten guinea pigs. The results showed that, in guinea pig temporal bone was similar to other animals and had three parts; squamous, tympanic and petrous .The tympanic part was much better developed and consisted of oval shaped tympanic bulla with many re...

Fourteen spontaneous tumors of an inbred strain of guinea pigs have been described. No tumors were found in guinea pigs under 3 years of age, thus supporting the ob servation of Papanicolaou and Olcott (43) that spontaneous tumors occur rarely in guinea pigs which do not survive to senility. While this constitutes an incidence of only 2.4 per cent of the total population of this colony, it repr...

A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and to DNP-GL was performed in Hartley guinea pigs. Delayed hypersensitivity to DNP-PLL and DNP-GL could be transferred successfully only by means of sensitized cells from genetic responder guinea pigs and in most cases, only into those guinea pigs genetically capable of responding to PLL. The inability to transfer...

T lymphocytes purified from lymph nodes and spleens of chancre-immune, inbred strain 2 guinea pigs, when infused into syngeneic guinea pigs, conferred protection against challenge with Treponema pallidum subsp. pallidum Nichols. No protection was conferred by similar injections of cell suspensions from normal guinea pigs or guinea pigs immunized with T. phagedenis biotype Reiter or T. pallidum-...