In the last 20 years, cost and turnaround time for whole genome sequencing (WGS) has decreased dramatically, while number of genetic diseases known molecular basis steadily increased, as investigational new drug applications gene-targeted therapeutics (GTT). GTTs have potential to transform outcomes in disorders by directly targeting causative defect. The United States Congress Food Drug Admini...

Purpose. The study is focused on development of high-fat, high-carbohydrate diet-induced experimental model metabolic syndrome (MS) in rats. Materials and methods. 6-week old Wistar rats ( n = 20) were used for study. Rats separated into control groups. from the group fed standard rat chow. had a diet rich lard (17%) fructose drank 20% solution. At end study, body weight blood pressure (BP) ass...

The levels of plasma high density lipoprotein (HDL) cholesterol and plasma triglyceride were determined in 44 patients with motor neuron disease (MND) and in 36 patients with spinocerebellar degeneration (SCD). In both groups the HDL cholesterol levels were significantly lower than those in healthy controls, whereas the plasma triglyceride levels were higher than those in the controls. Glucose ...

We introduce Geometric Texton Theory (GTT), a theory of categorical visual feature classification that arises through consideration of the metamerism that affects families of co-localised linear receptive-field operators. A refinement of GTT that uses maximum likelihood (ML) to resolve this metamerism is presented. We describe a method for discovering the ML element of a metamery class by analy...

This paper describes our experiments run to address the ad hoc task of the TREC 2005 Genomics track. The task topics were expressed with 5 different structures called Generic Topic Templates (GTTs). We hypothesized the presence of GTTspecific structural terms in the free-text fields of documents relevant to a topic instantiated from that same GTT. Our experiments aimed at extracting and selecti...

The approach of using a random matrix for extended object and group target tracking (EOT and GTT) is efficient. Designing and effectively applying this approach rely on modeling the extended object and group targets accurately. To describe complex dynamical variation and practical observation distortion of the extension in size, shape and orientation, two random matrix based models are proposed...

Materials The following materials were purchased from Sigma-Aldrich: sulfuric acid (H2SO4), hydrogen peroxide solution (H2O2), (3-aminopropyl)triethoxysilane (APTES), N-(3-dimethylaminopropyl)-N′ethylcarbodiimide (EDC), N-hydroxysuccinimide (NHS), succinic anhydride (SA), magnesium acetate solution, dimethyl sulfoxide (DMSO), triethylamine (TEA), and tris-EDTA buffer solution. The following DNA...

OBJECTIVE Previous studies showed that insulin stimulated directly calcitonin (Ct) secretion in the pig thyroid, while dexamethasone stimulated the production of Ct and Ct mRNA in medullary thyroid carcinoma (MTC) cell lines. The objective of this study was to investigate if hyperinsulinemia during the oral glucose tolerance test (GTT) stimulates Ct secretion in normal subjects as well as to ex...