Abstract Interleukin-9 (IL-9)-producing CD4 +T helper cells (Th9) have been implicated in allergy/asthma and anti-tumor immunity, yet molecular insights on their differentiation from activated T cells, driven by IL-4 transforming growth factor-beta (TGF-β), is still lacking. Here we show opposing functions of two transcription factors, D-binding protein (DBP) E2F8, controlling Th9 differentiati...

Background: Growth differentiation factor -9B (GDF-9B) is an oocyte derived growth factor, this protein is essential for development of ovarian follicles and act mainly by binding to its receptor on the surface of granulosa cells. The effect of this factor on the growth of follicles in various developmental stages particularly primordial and primary follicles is unknown. The aim of this study w...