A system for Do-It-Yourself (DIY) interface designs focused on sound and music computing has been developed. The system is based on the Create USB Interface (CUI), which is an open source microcontroller prototyping board together with the GROVE system of interchangeable transducers. Together, these provide a malleable and fluid prototyping process of ‘Sketching in Hardware’ for both music and ...

A complete characterization of DNA binding agents requires that their mode of binding to DNA be established. In the absence of high resolution structural data, the mode of binding is, of necessity, usually inferred indirectly from various solution studies. The purpose of this study is to show that only certain methods can be used reliably to infer the DNA binding mode. Comparative fluorescence ...

The nucleoprotein (NP) binds the viral RNA genome as oligomers assembled with the polymerase in a ribonucleoprotein complex required for transcription and replication of influenza A virus. Novel antiviral candidates targeting the nucleoprotein either induced higher order oligomers or reduced NP oligomerization by targeting the oligomerization loop and blocking its insertion into adjacent nucleo...

TGR5 (Gpbar-1, M-Bar) is a class A G-protein coupled bile acid-sensing receptor predominately expressed in brain, liver and gastrointestinal tract, and a promising drug target for the treatment of metabolic disorders. Due to the lack of a crystal structure of TGR5, the development of TGR5 agonists has been guided by ligand-based approaches so far. Three binding mode models of bile acid derivati...

We consider the following problem as defined by Grove et al. [5]: Given a set of n isothetic rectangles in 3D space determine the subset of rectangles that are not completely hidden. We present an optimal algorithm for this problem that runs in O(nlogn) time and O(n) storage. Our result is an improvement over the one of Grove et al. by a logarithmic factor in storage and is achieved by using a ...

The product of the Escherichia coli modE gene, ModE, is a member of a unique class of molybdate-responsive DNA binding proteins. Here we investigated the roles of the N- and C-terminal domains of ModE in mediating DNA binding and protein dimerization, respectively. Compared to the full-length protein, the N-terminal half of ModE has a greatly diminished capacity to bind the modA promoter in vit...

The Umari Dham is a sacred grove situated at the Jamwa Ramgarh Wildlife Sanctuary, Jaipur District of Rajasthan, India. It’s beautiful arbour near city Jaipur. has temple, which been visited by worshippers for approximately 450 years. During present field investigation, attempts were made to categorize floral diversity this grove, and around 215 flowering plant species belonging 159 genera unde...