effects of intra-articular administration of granisetron on temporomandibular joint (TMJ) pain was investigated in 11 patients with chronic polyarthritides. An analgesic effect superior to placebo has been shown previously. The change in TMJ movement pain intensity was negatively correlated to circulating 5-HT; that is, the higher the 5-HT before injection, the greater the reduction of pain int...

background post-operative nausea and vomiting (ponv) is one of the common problems after laparoscopic cholecystectomy. objectives the current study aimed to compare dexamethasone effect with that of granisetron in prevention of ponv. patients and methods in the current study 104 patients aged 20-60 with asa class i or ii who were candidates for laparoscopic cholecystectomy were included in the ...

cancer patient receive various cytotoxic drugs in association with antiemetic drugs such as 5ht3 receptor antagonists as their chemotherapy regimen. 5ht3 receptor antagonists have been reported to produce changes in ecg parameter. there are only a few studies about cardiovascular events of these drugs in patient receiving potentially cardiotoxic chemotherapies. the subject of this study is to e...

Transdermal medication delivery systems provide systemic therapy by passive diffusion through the skin. They offer an alternative route of medication administration and may be well suited for patients who are unable to take or retain oral medications. Granisetron transdermal system (Sancuso(R), ProStrakan, Inc.) is the first transdermal medication patch indicated for the prevention of nausea an...

The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.

Spinal anesthesia significantly results in shivering and hypothermia as unwanted effect. Shivering increases oxygen consumption which may be deleterious patients who have low cardiac pulmonary reserve. We conducted this study to evaluate the efficacy of Ketamine Granisetron for prevention under spinal anesthesia. In randomized prospective study, 90 Patients aged 18-60 years ASA physical status ...

CONTEXT AND OBJECTIVE Chemotherapy-induced emesis is a limiting factor in treating children with malignancies. Intensive chemotherapy regimens along with emetogenic drug administration have increased the frequency and severity of emesis and nausea. Our study was designed to consider the importance of this problem and the need for improvement in emesis treatment for patients receiving chemothera...

BACKGROUND To give prophylactics or timely treatment for post-operative nausea and vomiting (PONV) is the question. We compared the intensity and number of disturbing post-operative symptoms (i.e. pain, PONV, headache, fatigue, etc.) after prophylactic antiemetic treatment in a group of patients with >30% risk for post-operative vomiting. METHODS Four hundred and ninety-five patients, from th...

Exposure of sensitised intestine to specific allergen is known to produce appreciable reduction in water and electrolyte absorption. The mediators participating in this process have not been fully characterised. The effects of the 5-hydroxytryptamine2 (5-HT2) and 5-HT3 receptor antagonists, ketanserin and granisetron, respectively, on water movement during intestinal anaphylaxis were studied. H...