Transplanted neurons derived from stem cells have been proposed to improve function in animal models of human disease by various mechanisms such as neuronal replacement. However, whether the grafted neurons receive functional synaptic inputs from the recipient's brain and integrate into host neural circuitry is unknown. Here we studied the synaptic inputs from the host brain to grafted cortical...

Polyethersulfone (PES) based nanocomposite nanofiltration membrane was prepared by immersion precipitation method and casting solution technique using  poly (acrylic acid) grafted-iron oxide nanoparticles (Fe3O4) as hydrophilic filler additives. For this purpose, iron oxide nanoparticles were modified by in situ polymerization of acrylic acid in aqueous solution by potassium persulfate as initi...

Graft rejection is the major limiting factor in islet transplantation and is closely related with the recruitment and activation of T cells and macrophages against the graft. To reduce the immunogenicity of islets, we have grafted biocompatible polyethylene glycol (PEG) onto the collagen capsule of islets without changing the morphology and function of islets. In this study, we evaluated whethe...

This 3-year follow-up study compares implant treatment in 39 1-stage sinus-inlay block-grafted patients (study group) with 37 patients treated without bone grafting (reference group), all of whom were edentulous in the maxilla and were treated over the same time period. The cumulative success rate (CSR) of implant stability after 3 years in the study group was 75.3% in grafted areas and 82.2% i...

In this paper, we report the formation of hierarchically self-assembled nanofiber films from amylose-grafted sodium carboxymethyl celluloses (NaCMCs) that were synthesized by a chemoenzymatic approach. First, maltooligosaccharide primer-grafted NaCMCs were prepared by a chemical reaction using two kinds of NaCMCs with different degrees of polymerization (DPs) from Avicel and cotton sources. The...

Substitution of degenerated dopaminergic (DA) neurons by intrastriatally transplanted ventral mesencephalon (VM)-derived progenitor cells has been shown to improve motor functions in parkinsonian patients and animal models, whereas investigations of electrophysiological properties of the grafted DA neurons have been rarely performed. Here we show electrophysiological properties of grafted VM pr...

Methyl methacrylate (MMA) was successfully grafted onto cellulose nanofibers (CNFs) at room temperature in an emulsion system using a diethyl(1,10-phenanthroline N1,N10)zinc(II) complex (Phen-DEZ) with oxygen as the radical initiator. The effects of reaction temperature, initiator concentration, and monomer content on grafting were investigated. molecular weight non-grafted PMMA, which produced...

Background The aim of this study was to evaluate the effect of L-carnitine as an antioxidant on transplantation of ovarian tissue. MaterialsAndMethods Ovaries from 6-week old mice were grafted into back muscle. Transplanted ovaries were divided into three groups. 150 mg/Kg LC (solved in normal saline) was injected intraperitoneally one hour before surgical operation and repeated one other day u...