the present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (i/r) injury in rats.forty male rats were randomly divided into sham, control (i/r injury) and three crocin-pretreated groups. to induce i/r lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. pretreated-rats rec...

The expression and activity of selenoenzymes are regulated by Se. In the present study, the effects of different forms and concentrations of Se on the regulation of glutathione peroxidase (GPx) activity and phospholipid hydroperoxide GPx (GPx4) and type I deiodinase (D1) mRNA levels in chicken hepatocytes were evaluated. Primary cultured chicken hepatocyte monolayers derived from male White Leg...

In this study, the oxidative stress effects of cadmium (Cd) toxicity depending on water temperature were investigated Gammarus pulex. The test organism individuals exposed to sublethal concentrations for 96 hours at certain rates (C1; 1/10, C2; 1/20 and C3; 1/40) LC50 values Cd each (10, 14, 18 °C). Malondialdehyde (MDA) level, glutathione peroxidase (GPx), catalase (CAT) enzyme activities temp...

supplementation has beneficial effects in immune system and can antioxidant enzymes activity increases during the exercise and protects the tissue against the oxidative stress. l-carnitine is a famous supplement and helps to protect against the oxidative stress during and after intense or prolonged exercise. the aim of this study was to investigate the effect of l-carnitine supplementation on t...

In this study, some biochemical responses of Cyfluthrin (CFT), a commercial insecticide in Dreissena polymorpha, were investigated. The 96 hour LC50 value CFT on D. polymorpha was calculated as 553.22 ± 27.3 µg / L. exposed to subletal concentrations (1/20, 1/10 and 1/5 value) for 24 hours. enzyme activities superoxide dismustase (SOD), catalase (CAT) glutathione peroxidase (GPx) determined ind...

p53-mediated apoptosis may involve the induction of redox-controlling genes, resulting in the production of reactive oxygen species. Microarray expression analysis of doxorubicin exposed, related human lymphoblasts, p53 wild-type (WT) Tk6, and p53 mutant WTK1 identified the p53-dependent up-regulation of manganese superoxide dismutase (MnSOD) and glutathione peroxidase 1 (GPx). Consensus p53 bi...

BACKGROUND Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke risk. METHODS AND RESULTS We recently developed a genetic mouse model...

BACKGROUND Brazil nuts provide a rich natural source of selenium, yet no studies have investigated the bioavailability of selenium in humans. OBJECTIVE We investigated the efficacy of Brazil nuts in increasing selenium status in comparison with selenomethionine. DESIGN A randomized controlled trial was conducted with 59 New Zealand adults. Participants consumed 2 Brazil nuts thought to prov...

Hepatic ischemia-reperfusion (I-R) injury causes acute organ damage or dysfunction, and remains a problem for liver transplantation. In the I-R phase, the generation of reactive oxygen species aggravates the injury. In the current study, a novel selenocysteine-containing 7‑mer peptide (H-Arg-Sec-Gly-Arg-Asn-Ala-Gln-OH) was constructed to imitate the active site of an antioxidant enzyme, glutath...

Reactive oxygen species produced during the innate immune response to LPS are important agents of anti-pathogen defence but may also cause oxidative lung damage. Glutathione peroxidase-1 (gpx-1) is an anti-oxidant enzyme that may protect lungs from such damage. We assessed the in vivo importance of gpx-1 in LPS-induced lung inflammation. Male wild-type (WT) or gpx-1 deficient (gpx-1(-/-)) mice ...