نتایج جستجو برای: gpi

تعداد نتایج: 4043  

Journal: :The Journal of Cell Biology 1991
S Mayor A K Menon G A Cross

Glycosylinositol phospholipid (GPI) membrane anchors are the sole means of membrane attachment of a large number of cell surface proteins, including the variant surface glycoproteins (VSGs) of the parasitic protozoan, Trypanosoma brucei. Biosynthetic data suggest that GPI-anchored proteins are synthesized with carboxy-terminal extensions that are immediately replaced by GPI, suggesting the exis...

Journal: :The Journal of Cell Biology 1999
Jürgen H. Benting Anton G. Rietveld Kai Simons

Glycosyl-phosphatidylinositol (GPI)- anchored proteins are preferentially transported to the apical cell surface of polarized Madin-Darby canine kidney (MDCK) cells. It has been assumed that the GPI anchor itself acts as an apical determinant by its interaction with sphingolipid-cholesterol rafts. We modified the rat growth hormone (rGH), an unglycosylated, unpolarized secreted protein, into a ...

Journal: :Molecular & cellular proteomics : MCP 2003
Felix Elortza Thomas S Nühse Leonard J Foster Allan Stensballe Scott C Peck Ole N Jensen

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a functionally and structurally diverse family of post-translationally modified membrane proteins found mostly in the outer leaflet of the plasma membrane in a variety of eukaryotic cells. Although the general role of GPI-APs remains unclear, they have attracted attention because they act as enzymes and receptors in cell adhesion, dif...

Journal: :Blood 2005
Fabian Beier Stefan Balabanov Tom Buckley Klaus Dietz Ulrike Hartmann Markus Rojewski Lothar Kanz Hubert Schrezenmeier Tim H Brümmendorf

Telomere length has been linked to disease stage and degree of (pan-)cytopenia in patients with bone marrow failure syndromes. The aim of the current study was to analyze the impact of replicative stress on telomere length in residual glycosylphosphatidylinositol-positive (GPI+) versus GPI- hematopoiesis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Peripheral blood granulocytes f...

2008
Margot G. Paulick Carolyn R. Bertozzi

Positioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol (GPI) anchor is a posttranslational modification that anchors the modified protein in the outer leaflet of the cell membrane. The GPI anchor is a complex structure comprising a phosphoethanolamine linker, glycan core, and phospholipid tail. GPI-anchored proteins are structurally and functionally diverse a...

Journal: :The Journal of Cell Biology 1995
D Hamburger M Egerton H Riezman

Anchoring of proteins to membranes by glycosylphosphatidylinositols (GPIs) is ubiquitous among all eukaryotes and heavily used by parasitic protozoa. GPI is synthesized and transferred en bloc to form GPI-anchored proteins. The key enzyme in this process is a putative GPI:protein transamidase that would cleave a peptide bond near the COOH terminus of the protein and attach the GPI by an amide l...

Journal: :Bioscience, biotechnology, and biochemistry 2013
Yuri Mukai Masami Ikeda Hirotaka Tanaka Tatsuya Konishi Osamu Oura Takanori Sasaki

The glycosylphosphatidylinositol (GPI) attachment is a most important post-translational modification of proteins that plays essential roles in promoting the biochemical activities of eukaryotic cells. Described here is an analysis of the amino acid properties of mammalian GPI-anchored proteins (GPI-APs) and the development of an innovative method of detecting them. GPI-APs are characterized by...

Journal: :Stroke 1998
M A Helfaer R N Ichord L J Martin P D Hurn A Castro R J Traystman

BACKGROUND AND PURPOSE We previously showed that treatment with a competitive N-methyl-D-aspartate (NMDA) receptor antagonist GPI-3000 (GPI) improved short-term physiological recovery after incomplete global cerebral ischemia complicated by dense acidosis. We tested the hypothesis that GPI administered after resuscitation from cardiac arrest would improve a more long-term recovery as measured b...

Journal: :Digital Signal Processing 2010
Cheng-Hsiung Hsieh Ren-Hsien Huang

In this paper, the one-dimensional grey polynomial interpolation (1-D GPI) developed for image enlargement in [27] is applied to reduce the block effect in the block discrete cosine transform (BDCT) image/video coders. Note that the block effect in the BDCT coders results from insufficient bits for transform coefficients. An interpolation approach is proposed to relieve the block effect problem...

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