Human granulosa cells cultured with calf serum actively proliferated for 18-20 generation and secreted progesterone into the medium; progesterone levels appeared to decline with increase in generation number. Cells cultured under serum-free conditions secreted significant amounts of progesterone and insulin-like growth factor II (IGF-II). The progesterone secretion was enhanced by the addition ...

In their review article, Drs. Crawford and Moul seek to describe the cardiovascular (CV), renal, and pulmonary complications associated with the use of long-term androgen deprivation therapy (ADT) in men with prostate cancer.[1] Furthermore, they attempt to determine whether there is a difference in CV and renal complications between different types of ADT, including luteinizing hormone–releasi...