The aim of this study was to evaluate the efficacy and safety of an anti-hypercholesterolemic agent containing Berberis aristata, Silybum marianum and monacolin K and KA in a sample of Caucasian patients at low cardiovascular risk according to Framingham score. The primary outcome was to evaluate the effects of this nutraceutical combination on lipid profile; the secondary outcome was to evalua...

The medicinal plants find application in pharmaceutical, cosmetic, agricultural and food industry. The efficacy of some herbal products is beyond doubt, the most recent examples being Silybum marianum (Linn.) Gaertn (silymarin), Artemisia annua Linn. (artemesinin) and Taxus baccata Linn. (taxol). Randomized, controlled trials have proved the efficacy of some established remedies, for instance Z...

Silymarin is an antihepatotoxic substance isolated from fruits of Silybum marianum. Possibly due to their antioxidant and membrane stabilizing properties, the compounds have been shown to protect different organs and cells against a number of insults. The content and composition of main silymarin components (silybin, isosilybin, silydianin and silychristin) in various pharmaceuticals were analy...

BACKGROUND Berberine is an isoquinoline alkaloid widely used to improve the glucidic and lipidic profiles of patients with hypercholesterolemia, metabolic syndrome, and type 2 diabetes. The limitation of berberine seems to be its poor oral bioavailability, which is affected by the presence, in enterocytes, of P-glycoprotein - an active adenosine triphosphate (ATP)-consuming efflux protein that ...

this experiment was conducted to evaluate the ability of silybum marianum seeds (sms) on performance, carcass variables, and liver morphology of the broiler chickens contaminated with aflatoxin b1 (afb1). a total of 216 broiler chicks (ross 308) were used. birds were randomly assigned to nine treatment groups, with four replicates and six birds in each replicate. chickens were reared on litter ...

background & aim: increasing of drug resistances and more attention to the hazards of side effects of synthetic drugs has caused extensive researches on medicinal plant resources. the aim of this study was to determination of the chemical composition of native silybum marianum and foeniculum vulgare extractions in ardabil, iran; and investigation of their anticancer effect on liver cancer cell ...

background: this study aims to evaluate the efficacy of silybum marianum seeds (smss) on blood biochemical profile of broiler chickens contaminated with aflatoxin b1 (afb1).  methods: combinations of three levels of afb1 (0, 250 and 500 ppb) with three levels of smss (0, 0.5, and 1.0 %) were incorporated into the basal diet (corn and soybean meal). the effect of nine experimental treatments was...