During the present century, a great deal of the earlier work has been confirmed and still further progress made in our knowledge of the problem. The application of iddine therapy in the prophylaxi s and treatment of goitre was commenced. In America in 1910 Marine found that goitre in brook trout could be prevented.by the administration of Iodine, subsequently he found the same, result to apply ...

IN 1932, Cecil Joll, in his book "Diseases of the Thyroid Gland" emphasised that "although respiratory symptoms due to tracheal compression and alteration of voice were common", dysphagia was a "decidedly rare feature of simple goitre". Since then there has been little documentation on the subject. The following is an account of the symptoms found in a series of patients undergoing surgery for ...

A case of histiocytosis X involving the thyroid and hypothalamus is reported. A 16 year old female presented with amenorrhoea and diabetes insipidus. She subsequently developed a painful goitre with biochemical hypothyroidism, and stridor. The stridor and goitre responded to cyclophosphamide. Previous publications on the use of cytotoxics in histiocytosis X involving the thyroid are reviewed. W...

The junior writer first broached the subject of intravenous injections of sodium iodide for the treatment of goitre with a view to testing:? (1) Whether sodium iodide orally was beneficial in cases of goitre. (2) Whether iodine is essential for the good functioning of the thyroid gland. (3) Whether the oral administration of sodium iodide could prevent the disease. He suggested that it might be...

Iodine goitre and hypothyroidism in 5 newborn infants in an intensive care unit were induced by cutaneous absorption of iodine, after numerous skin applications of iodine alcohol. The infant's skin permeability allows severe iodine overloading of the thyroid, resulting in goitre and hypothyroidism. Ioduria should always be sought in a newborn infant showing hypothyroidism. Iodine should not be ...

There is no ideal treatment for benign multinodular goitre. Besides surgery, which is recommended for large goitres or when malignancy cannot be excluded, the non-surgical treatment options are levothyroxine therapy and radioiodine ((131)I) therapy. Conventional (131)I therapy [without recombinant human thyroid-stimulating hormone (rhTSH)] has been used for more than a decade in symptomatic non...

The use of thyroid preparations to reduce the size of non-toxic goitres is well established, as is their use in differentiating between high 1311 uptake rates due to thyrotoxicosis and those occurring in non-toxic goitres (Greer and Smith, 1954; Werner and Spooner, 1955). It would seem reasonable to expect that the amount by which the thyroidal 1311 uptake can be suppressed by thyroid preparati...