نتایج جستجو برای: gm1 receptor assay

تعداد نتایج: 787759  

Journal: :The American journal of tropical medicine and hygiene 2001
B A Oyofo D S Subekti A M Svennerholm N N Machpud P Tjaniadi T S Komalarini B Setiawan J R Campbell A L Corwin M Lesmana

Infection caused by enterotoxigenic Escherichia coli (ETEC) poses a serious health problem among children and adults in developing countries. Colonization of the small intestinal mucosa by ETEC strains is mediated by antigenically specific fimbriae, also known as colonization factor antigens (CFA). The significance of this study arises from reports that active and passive immunization with ETEC...

Journal: :Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2005
Peter A Csurhes Alice-Ann Sullivan Kerryn Green Judith M Greer Michael P Pender Pamela A McCombe

This study was performed to determine whether increased ganglioside-specific T cell reactivity can be detected in the peripheral blood of patients with Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). T cell responsiveness to the gangliosides GM1, GM3, GD1a, GD1b, GD3, GT1b, GQ1b and sulphatide was assessed in peripheral blood mononuclear cells...

Journal: :Journal of microbiology and biotechnology 2009
Jung-Gu Lim Jung-Ae Kim Hea-Jong Chung Tae-Geum Kim Jung-Mi Kim Kyung-Ryul Lee Seung-Moon Park Moon-Sik Yang Dae-Hyuk Kim

Although the Escherichia coli heat-labile enterotoxin B subunit (LTB) has already been expressed in several different systems, including prokaryotic and eukaryotic organisms, studies regarding the synthesis of LTB into oligomeric structures of pentameric size in the budding yeast Saccharomyces cerevisiae have been limited. Therefore, this study used a functional signal peptide of the amylase 1A...

2016
Susan K. Halstead Gabriela Kalna Mohammad B. Islam Israt Jahan Quazi D. Mohammad Bart C. Jacobs Hubert P. Endtz Zhahirul Islam Hugh J. Willison

OBJECTIVE To characterize the patterns of autoantibodies to glycolipid complexes in a large cohort of Guillain-Barré syndrome (GBS) and control samples collected in Bangladesh using a newly developed microarray technique. METHODS Twelve commonly studied glycolipids and lipids, plus their 66 possible heteromeric complexes, totaling 78 antigens, were applied to polyvinylidene fluoride-coated sl...

Journal: :The Journal of biological chemistry 1981
M J De Wolf M Fridkin M Epstein L D Kohn

The tryptophan residues on cholera toxin and its A and B protomers have been modified by reaction with 2-nitrophenylsulfenyl chloride and 2,4-dinitrophenylsulfenyl chloride. Modification of the tryptophan residues of cholera toxin results in complete loss of toxicity measured in a skin permeability assay. Modification of cholera toxin and its B protomer results in the complete loss of binding a...

2015
Delmont Emilien Willison Hugh

A wide range of autoantibodies have been described in immune-mediated nerve disorders that target glycans borne by glycolipids and glycoproteins enriched in the peripheral nerves. Their use as diagnostic biomarkers is very widespread, despite some limitations on sensitivity and specificity, and the lack of standardized assays and access to quality assurance schemes. Although many methods have b...

Journal: :Brain research 2007
Hiroyuki Satoh Osamu Yamato Tomoya Asano Madoka Yonemura Toyofumi Yamauchi Daisuke Hasegawa Hiromitsu Orima Toshiro Arai Masahiro Yamasaki Yoshimitsu Maede

The present study investigated cerebrospinal fluid (CSF) biomarkers for estimating degeneration of the central nervous system (CNS) in experimental dogs with GM1 gangliosidosis and preliminarily evaluated the efficacy of long-term glucocorticoid therapy for GM1 gangliosidosis using the biomarkers identified here. GM1 gangliosidosis, a lysosomal storage disease that affects the brain and multipl...

Journal: :Proceedings of the National Academy of Sciences 1995

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1993
A Dalia N H Neff M Hadjiconstantinou

Rat embryonic mesencephalic cultures were employed to evaluate the consequences of adding GM1 ganglioside to cultures lesioned with the selective neurotoxin 1-methyl-4-phenylpyridinium (MPP+). MPP+ reduced dopamine and DOPAC content, dopamine uptake, aromatic L-amino acid decarboxylase activity, and the number of tyrosine hydroxylase-immunopositive neurons. The immunopositive neurons that remai...

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