نتایج جستجو برای: gm1

تعداد نتایج: 1944  

2015
Lotte Vlam Elisabeth A. Cats Oliver Harschnitz Marc D. Jansen Sanne Piepers Jan Herman Veldink Hessel Franssen Abraham C.J. Stork Erik Heezius Suzan H.M. Rooijakkers Bjorn L. Herpers Jos A. van Strijp Leonard H. van den Berg W. Ludo van der Pol

OBJECTIVE To investigate whether high innate activity of the classical and lectin pathways of complement is associated with multifocal motor neuropathy (MMN) and whether levels of innate complement activity or the potential of anti-GM1 antibodies to activate the complement system correlate with disease severity. METHODS We performed a case-control study including 79 patients with MMN and 79 m...

Journal: :Biochimica et biophysica acta 2017
Moutusi Manna Matti Javanainen Hector Martinez-Seara Monne Hans-Joachim Gabius Tomasz Rog Ilpo Vattulainen

Extracellular and cytosolic leaflets in cellular membranes are distinctly different in lipid composition, yet they contribute together to signaling across the membranes. Here we consider a mechanism based on long-chain gangliosides for coupling the extracellular and cytosolic membrane leaflets together. Based on atomistic molecular dynamics simulations, we find that long-chain GM1 in the extrac...

2013
Fulton P. Rivera Anicia M. Medina Sandra Bezada Roberto Valencia María Bernal Rina Meza Ryan C. Maves Theresa J. Ochoa

Secretory diarrhea caused by cholera toxin (CT) is initiated by binding of CT's B subunit (CTB) to GM1-ganglioside on the surface of intestinal cells. Lactoferrin, a breast milk glycoprotein, has shown protective effect against several enteropathogens. The aims of this study were to determine the effect of bovine-lactoferrin (bLF) on CT-induced intestinal fluid accumulation in mice, and the int...

Journal: :Journal of clinical microbiology 1983
C C Czerkinsky A M Svennerholm

A new method has been developed for demonstration of heat-labile (LT) enterotoxin produced by Escherichia coli. This method is based upon the release of LT from bacteria grown directly onto agar plates which have been coated with ganglioside GM1. Toxin bound to the GM1 solid state is subsequently demonstrated by means of a three-step immunoenzymatic procedure in which enzyme-substrate reactions...

Journal: :Metallomics : integrated biometal science 2013
Thomas H Osborne Matthew D Heath Andrew C R Martin Jaroslaw A Pankowski Karen A Hudson-Edwards Joanne M Santini

Polaromonas sp. str. GM1 is an aerobic, psychrotolerant, heterotrophic member of the Betaproteobacteria and is the only isolate capable of oxidising arsenite at temperatures below 10 °C. Sequencing of the aio gene cluster in GM1 revealed the presence of the aioB and aioA genes, which encode the arsenite oxidase but the regulatory genes typically found upstream of aioB in other members of the Pr...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Pablo H Lopez Gang Zhang Jiangyang Zhang Helmar C Lehmann John W Griffin Ronald L Schnaar Kazim A Sheikh

Anti-GM1 antibodies are present in some patients with autoimmune neurological disorders. These antibodies are most frequently associated with acute immune neuropathy called Guillain-Barré syndrome (GBS). Some clinical studies associate the presence of these antibodies with poor recovery in GBS. The patients with incomplete recovery have failure of nerve repair, particularly axon regeneration. O...

Journal: :Journal of the neurological sciences 2013
Jay S Schneider Stephen M Gollomp Stephanie Sendek Amy Colcher Franca Cambi Wei Du

The present single center, double-blind, delayed start study was conducted to examine possible symptomatic and disease-modifying effects of GM1 ganglioside in Parkinson's disease (PD). Seventy-seven subjects with PD were randomly assigned to receive GM1 for 120 weeks (early-start group) or placebo for 24 weeks followed by GM1 for 96 weeks (delayed-start group). Washout evaluations occurred at 1...

2009
Jason S. Mitchell Wells S. Brown Darren G. Woodside Peter Vanderslice Bradley W. McIntyre

Lipid rafts are small laterally mobile microdomains that are highly enriched in lymphocyte signaling molecules. GM1 gangliosides are a common lipid raft component and have been shown to be important in many T-cell functions. The aggregation of specific GM1 lipid rafts can control many T-cell activation events, including their novel association with T-cell integrins. We found that clustering GM1...

Journal: :Journal of neuroimmunology 2010
Eduardo Nobile-Orazio Claudia Giannotta Chiara Briani

Anti-ganglioside complexes (GSCs) IgG antibodies have been reported in patients with Guillain-Barré (GBS) or Fisher syndrome but little is known on their presence in multifocal motor neuropathy (MMN) or other chronic immune-mediated neuropathies. We examined 24 patients with MMN, 34 with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 23 with neuropathy associated with IgM mon...

Journal: :The Journal of biological chemistry 1998
J Kopitz C von Reitzenstein M Burchert M Cantz H J Gabius

Cell density-dependent inhibition of growth and neural differentiation in the human neuroblastoma cell line SK-N-MC are associated with a ganglioside sialidase-mediated increase of GM1 and lactosylceramide at the cell surface. Because these glycolipids expose galactose residues, we have initiated the study of the potential role of galectins in such cellular events. Using specific antibodies, ga...

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