An on-line coupled capillary isotachophoresis-capillary zone electrophoresis method for the determination of glycyrrhizin in liqueurs is described. The optimised electrolyte system was 5 mM HCl+11 mM epsilon-aminocaproic acid+0.05% hydroxyethylcellulose+30% methanol (leading electrolyte), 5 mM caproic acid+30% methanol (terminating electrolyte) and 20 mM caproic acid+10 mM histidine+0.1% hydrox...

This study was conducted to determine the effects of soil and climatic conditions on glycyrrhizic acid contents in various Iranian populations of Glycyrrhiza glabra in two root diameters. Twelve populations in arid, semi-arid and Mediterranean climates of different parts of Iran were collected and the content of glycyrrhizic acid was determined using HPLC. The results showed that contents of gl...

Recently emerging pandemic SARS CoV-2 conquered our world since December 2019. Continuous efforts have been done to find out effective immunization and precise treatment stetratigies A way from therapeutic options that were tried in CoV-2, an increased attention is directed predict natural products mainly phytochemicals as collaborative measures for this crisis. In review, most of the mentioned...

Since its pandemic in 2019, SARS-CoV-2 has badly affected the countries around globe. There is no FDA approved drug for treatment of disease. In this study, we evaluated potential targets against non-structural protein-1 (Nsp-1), which crucial disturbing host-translational machinery. As completecrystal structure Nsp-1 was not available, used I-TASSER making complete protein. The verified using ...

in vivo and in vitro sublethal exposure of abrin, glycyrrhizin (active component of abrus precatorius seed and root), sanguinarine, protopine (argemone mexicana seed) and oleandrin (nerium indicum leaf) inhibited the acetylcholinesterase, lactic dehydrogenase, acid and alkaline phosphatase activity in the nervous tissue of lymnaea acuminata. the succinic dehydrogenase activity in the nervous ti...

BACKGROUND High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis of pulmonary arterial hypertension. In this study, we explored the relationship between HMGB1 and pulmonary hypertension and whether glycyrrhizin, an inhibitor of HMGB1, attenuates disease progression in an animal mo...