نتایج جستجو برای: glycine rich loop

تعداد نتایج: 311334  

Journal: :Journal of neurochemistry 2002
Hans-Georg Breitinger Carmen Villmann Janine Rennert Diana Ballhausen Cord-Michael Becker

The human glycine receptor subunit alpha3 exists in two splice variants (alpha3K/L), with alpha3L bearing an additional segment of 15 amino acids within the cytoplasmic TM3-4 loop. Homomeric alpha3K glycine receptors show faster desensitization than alpha3L receptors. Ion channel properties were compared of alpha3L, alpha3K, and of the triple mutant alpha3LDeltaOH = alpha3L(T358A/Y367F/S370A), ...

Journal: :Molecular pharmacology 2011
Stephan A Pless Ariele P Hanek Kerry L Price Joseph W Lynch Henry A Lester Dennis A Dougherty Sarah C R Lummis

Cation-π interactions have been demonstrated to play a major role in agonist-binding in Cys-loop receptors. However, neither the aromatic amino acid contributing to this interaction nor its location is conserved among Cys-loop receptors. Likewise, it is not clear how many different agonists of a given receptor form a cation-π interaction or, if they do, whether it is with the same aromatic amin...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه کردستان - دانشکده علوم 1393

هدف این کار به دست آوردن خواص ترمودینامیکی و اثر آمینواسیدهای آلانین و گلیسین بر روی محلول های آبی پلیمری است. در بخش اول این کار، داده های تجربی فعالیت آب در دمای 15/298 کلوین برای سیستم ¬های سه-تایی (alanine + ppg400 + h2o)، (alanine + peg400 + h2o)، (alanine + peg2000 + h2o)، (alanine + peg10000 + h2o)، ((glycine + ppg400 + h2o، (glycine + peg400 + h2o)، (glycine + peg2000 + h2o) و (glycine ...

Journal: :Nucleic acids research 1999
K Maruyama N Sato N Ohta

The rbp gene family of the cyanobacterium Anabaena variabilis strain M3 consists of eight members that encode small RNA-binding proteins containing a single RNA recognition motif (RRM). Similar genes are found in the genomes of Synechocystis sp. PCC6803, Helicobacter pylori and Treponema pallidum, but are absent from the other completely sequenced prokaryotic genomes. The expression of the rbp ...

2014
Brian P. Tripet Katelyn E. Mason Brian J. Eilers Jennifer Burns Paul Powell Andreas M. Fischer Valérie Copié

The timing of whole-plant senescence influences important agricultural traits such as yield and grain protein content. Post-transcriptional regulation by plant RNA-binding proteins is essential for proper control of gene expression, development, and stress responses. Here, we report the three-dimensional solution NMR structure and nucleic acid-binding properties of the barley glycine-rich RNA-b...

Journal: :Neuron 1997
Bodo Laube Hirokazu Hirai Mike Sturgess Heinrich Betz Jochen Kuhse

NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel activation. The glycine binding site of these heteromeric receptor proteins is formed by regions of the NMDAR1 (NR1) subunit that display sequence similarity to bacterial amino acid binding proteins. Here, we demonstrate that the glutamate binding site is located on the homologous regions of the NR2B subunit...

Journal: :The Journal of biological chemistry 2004
Nils Schrader Eun Young Kim Jan Winking Jens Paulukat Hermann Schindelin Günter Schwarz

Gephyrin is an essential and instructive molecule for the formation of inhibitory synapses. Gephyrin binds directly to the large cytoplasmic loop located between transmembrane helices three and four of the beta-subunit of the glycine receptor and to microtubules, thus promoting glycine receptor (GlyR) anchoring to the cytoskeleton and clustering in the postsynaptic membrane. Besides its structu...

Journal: :Biochemistry 2014
Rilei Yu Eliott Hurdiss Timo Greiner Remigijus Lape Lucia Sivilotti Philip C Biggin

The human glycine receptor (hGlyR) is an anion-permeable ligand-gated channel that is part of a larger superfamily of receptors called the Cys-loop family. hGlyRs are particularly amenable to single-channel recordings, thus making them a model experimental system for understanding the Cys-loop receptor family in general. Understanding the relationship between agonist binding and efficacy in Cys...

Journal: :The Journal of biological chemistry 1969
Y Ogawa G Quagliarotti J Jordan C W Taylor W C Starbuck H Busch

1. The amino acid sequence of the amino-terminal portion of the glycine-rich, arginine-rich histone (Residues 1 to 49) has been determined from studies on the tryptic, chymotryptic, and thermolysin peptides. This sequence overlaps with that of the carboxylterminal portion (Residues 50 to 102) defined previously to give the following sequence: acetylserGly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید