In many species benzoate is conjugated in the liver with glycine to form hippurate, after prior formation of benzoyl-CoA, which then reacts with glycine in a transacylation catalysed by glycine N-acylase (EC 2.3.1.13) (Bridges et al., 1970). This enzyme has been prepared from mitochondria (Schachter & Taggart, 1954; Bartlett & Gompertz, 1974), although there is no information about its submitoc...

Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended clinical trials so far have been hampered by the fact that conventional approaches to produce these antibodies suffer from low yields, ill-defined byproducts, or laborious purification procedures. To overcome this problem, we have generated a small, recombinant, lymp...

Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended clinical trials so far have been hampered by the fact that conventional approaches to produce these antibodies suffer from low yields, ill-defined byproducts, or laborious purification procedures. To overcome this problem, we have generated a small, recombinant, lymp...

The glycine receptor is a member of the ligand-gated ion channel receptor superfamily that mediates fast synaptic transmission in the brainstem and spinal cord. Following ligand binding, the receptor undergoes a conformational change that is conveyed to the transmembrane regions of the receptor resulting in the opening of the channel pore. Using the acetylcholine-binding protein structure as a ...

Huang, H. 2017. Quinone-Pyrrole Dyad Based Polymers for Organic Batteries. From Design to Application. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1483. 73 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9832-0. Organic electrode materials are finding increasing use in energy storage devices due to their attractive properties ...

Highly protein-resistant, self-assembled monolayers (SAMs) of dendritic polyglycerols (PGs) on gold can easily be obtained by simple chemical modification of these readily available polymers with a surface-active disulfide linker group. Several disulfide-functionalized PGs were synthesized by N,N'-dicyclohexylcarbodiimide-mediated ester coupling of thioctic acid. Monolayers of the disulfide-fun...

Interferon gamma (IFN-γ), a signal proinflammatory cytokine secreted by immune cell, and plays a critical role in the pathogenesis and progression of many diseases. It has been regarded as an important marker for determination of disease-specific immune responses. Therefore, it is urgent to develop a feasible and accurate method to detect IFN-γ in clinic real blood samples. Until now, the immun...