From evidence obtained by nuclear magnetic resonance, mass and infrared spectrometry, and chemical techniques, these compounds were identified as cis-4-decene-1, lodioic, cis,cis-4,7-decadiene-1, IO-dioic, cis-4-octene-1,8dioic, glutaric, and adipic acids, N-isovalerylglycine, and N-(methylenecyclopropyl)acetylglycine. (2 KE JOME JH YL ENE CYCLOPROP YL PROPIONiC CH =C8HCH 3 D COCOOH ACID / KMCP...

organic acidemias are the group of metabolic disorders which define by high anion gap metabolic acidosis, hypo or hyperglycemia & hyperammonemia.because of the severity of disease in children and its fatality in severe form of disease and also need for life long treatment, prenatal diagnosis is an important diagnostic tool.three approaches to prenatal diagnosis may be possible, including measur...

A homologous series of anionic gas-phase clusters of dicarboxylic acids (oxalic acid, malonic acid, succinic acid, glutaric acid, and adipic acid) generated via electrospray ionization (ESI) are investigated using collision-induced dissociation (CID). Sodiated clusters with the composition (Na(+))(2)(n+1)(dicarboxylate(2-)(n+1) for singly charged anionic clusters, where n = 1-4, are observed as...

In preceding reports from this laboratory, a-hydroxyanthranilic acid was shown to be converted to glutaric acid and COz by crude extracts of cat liver (l-3). Evidence was also presented that ol-amino-p-carboxymuconic e-semialdehyde, the primary oxidation product of 3-hydroxyanthranilic acid by the oxygenase (4), is an obligatory intermediate in this conversion (2,3). However, all previous exper...

Cloud condensation nucleus (CCN) experiments were carried out for malonic acid, succinic acid, oxalacetic acid, DL-malic acid, glutaric acid, DL-glutamic acid monohydrate, and adipic acid, using both water and methanol as atomization solvents, at three operating supersaturations (0.11%, 0.21%, and 0.32%) in the Caltech three-column CCN 5 instrument (CCNC3). Predictions of CCN behavior for five ...

After EATCS was officially founded in 1972 the Bulletin issuer one was edited by Maurice Nivat in 73, issue two by Giorgio Ausiello in 76. I was elected EATCS Secretary and Bulletin editor at the 4 th ICALP (Turku, 1977) The regular appearance (three issues a year) was started by me with issue three: I am happy that some of the logo-design and structure that we introduced (particular the ideas ...

Drug discovery and development is generally done in the commercial rather than the academic realm. Drug discovery involves target discovery and validation, lead identification by high-throughput screening, and lead optimization by medicinal chemistry. Follow-up preclinical evaluation includes analysis in animal models of compound efficacy and pharmacology (ADME: administration, distribution, me...

Glutaric acidemia (GA-1) is an autosomal recessive disorder of lysine, hydroxylysine,and tryptophan metabolism caused by deficiency of glutaryl-CoA dehydrogenase. It results in the accumulation of 3-hydroxyglutaric and glutaric acid. Affected patients can present with brain atrophy and macrocephaly and with acute dystonia secondary to striatal degeneration in most cases triggered by an intercur...