BACKGROUND/AIMS Despite a proposed role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis, antioxidant approaches have not been investigated sufficiently in the therapy of nonalcoholic steatohepatitis. Our aim was to determine whether vitamin E plus C therapy is effective in normalization of liver enzymes compared to ursodeoxycholic acid treatment in patients with fatty li...

To the Editor: A 50‐year‐old man presented with recurrent episodes of bullae, erosions, and crust on sun‐exposed areas for 1 year. Lesions healed with scarring and hyperpigmentation. The skin lesions were aggravated after sun exposure. The patient had a 30‐year alcohol abuse (100–200 ml/day) history. Family heredity history was unremarkable. Physical examination revealed multiple erosions with ...

Aspartate aminotransferase-to-platelet ratio (APRI), aspartate aminotransferase-to-alanine aminotransferase ratio (AAR), FIB-4, FI, King, Lok, Forns, and FibroIndex scores may be simple and convenient noninvasive diagnostic tests, because they are based on the regular laboratory tests and demographic data. This study aimed to systematically evaluate their diagnostic accuracy for the prediction ...

In domestic animal medicine, changes in serum enzyme levels are routinely used as diagnostic tools to detect liver disease. Hepatic disease occurs in pinnipeds, but limited data are available on the tissue distribution of serum enzymes in marine mammals. The objectives of this study were to determine the tissue distribution of seven serum enzymes in three pinniped species. Enzymes evaluated wer...

the ameliorative activity of aqueous extract of the flesh of dates (phoenix dactylifera l.) and ascorbic acid on thioacetamide-induced hepatotoxicity was studied in rats. sixty male rats were divided into six equal groups of 10. two groups were controls, one treated with thioacetamide and one with only distilled water. two groups received extract of flesh phoenix dactylifera and intraperitoneal...

Dysmetabolic iron overload syndrome (DIOS) corresponds to the increase in stores associated with components of metabolic (MtS) and absence an identifiable cause excess. The objective this work was review main aspects DIOS. PUBMED EMBASE were consulted, PRISMA guidelines followed. DIOS is usually asymptomatic can be diagnosed by investigating MtS steatosis. About 50% patients present altered hep...

The relation between alcohol consumption and blood pressure is well recognized, and advice to reduce alcohol plays an important part in the management of hypertensive patients. We have evaluated the effectiveness of this advice in a randomized, controlled, single-blind clinical study. After a 2-week run-in period, hypertensive men regularly consuming more than 20 units/wk (1 unit = 10 g) of alc...

The current research work was undertaken to evaluate the hepatoprotective and nephroprotective potential of Cichorium intybus following subchronic exposure imidacloprid in white leghorn (WLH) chicks. Thirty, 6 8 weeks old chicks 300-350 g weight were randomly equally divided into five groups. Group I served as control fed normal grower ration other medicated containing leaf powder @ 5000 ppm II...

Abstract Background Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides, and also hepatokine. Hepatocyte-specific overexpression of DPP4 associated with hepatic insulin resistance liver steatosis. Method We examined whether weekly inhibitor omarigliptin (OMG) can improve function as well levels inflammation in type 2 diabetic patients non-alcoholic fa...

background: the alcoholic decoction of root ethanolic extract of aristolochia ringens is taken orally to treat various ailments in south-west nigeria without prior knowledge of its potential toxic effect. therefore, this study aimed at assessing the toxicity potentials of root ethanolic extract of a. ringens on functional indices and histology of the liver. methods: twenty male rats were random...