BACKGROUND Glomerular filtration rate (GFR) is a widely accepted parameter in assessing overall renal function. This study sought to assess the effect of glucose lowering on GFR in diabetic patients admitted for short term therapy at Mulago hospital. METHODS This was a descriptive study where consenting patients were consecutively recruited. Glomerular filtration rate was measured using creat...

Qi, Zhonghua, Irene Whitt, Amit Mehta, Jianping Jin, Min Zhao, Raymond C. Harris, Agnes B. Fogo, and Matthew D. Breyer. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol 286: F590–F596, 2004. First published November 4, 2003; 10.1152/ ajprenal.00324.2003.—Two nonradioactive methods for determining glomerular filtration r...

1. In male Wistar rats urinary kallikrein excretion was positively correlated with urinary flow and glomerular filtration rate (GFR). 2. Osmotic diuresis produced by a 30% (w/v) glucose solution increased urinary kallikrein, and a positive correlation between this variable and urine flow was observed. No correlation was observed with GFR. 3. The mechanism of urinary kallikrein excretion is inte...

• Several glomerular filtration rate (GFR) prediction equations that take into account the serum creatinine concentration and certain patient variables (age, gender, body size and/or race) have been shown to generate sufficiently precise, unbiased and accurate estimates of GFR (eGFR) to be clinically useful for evaluating kidney function in a broad range of clinical settings. (Level III evidenc...

Background Chronic kidney disease is a major microvascular complication of Diabetes Mellitus (DM) and may affect about one third of the patients. Based on the evidence that a proportion of patients may have reduced glomerular filtration rate (GFR) without increased albuminuria, it is recommended to evaluate both parameters. Furthermore, both of them are considered prognostic factors of renal an...

Acute renal failure (ARF) is a sudden decrease in glomerular filtration rate (GFR) where GFR represents the amount of blood that is filtered by the kidneys. The kidneys are responsible for numerous physiologic processes including excretion of toxic metabolites and maintaining appropriate fluid balance in the body. Thus, ARF can result in a sudden, potentially life-threatening, dysregulation of ...

BACKGROUND Detecting impaired glomerular filtration rate (GFR) is important in intensive care units (ICU) in order to diagnose acute kidney injuries and adjust the dose of renally excreted drugs. Whether serum Cystatin C (SCysC) may better reflect glomerular filtration rate than serum creatinine (SCr) in the context of intensive care medicine is uncertain. METHODS We compared the performance ...

The rate of decline of glomerular filtration rate (GFR) in children with chronic kidney disease (CKD) can vary, even among those with similar diagnoses. Classic regression methods applied to the log-transformed GFR (i.e., lognormal) quantify only rigid shifts in a given outcome. The generalized gamma distribution offers an alternative approach for characterizing the heterogeneity of effect of a...

1. Amino acids have been used to test renal reserve filtration capacity. Previous studies suggest that amino acids increase glomerular filtration rate (GFR) by reducing distal tubular flow and tubuloglomerular feedback activity. 2. Glomerular function and the renal tubular handling of sodium during infusion of amino acids was studied in 12 normal volunteers. 3. Clearance of sodium (CNa) was unc...