نتایج جستجو برای: global drug
تعداد نتایج: 1021415 فیلتر نتایج به سال:
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats. Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four g...
Background Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major global health problem. It is the second leading cause of death worldwide. Drug resistance threatens global TB control with the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) TB. The burden of MDR TB and XDR TB in India is not available as continuous surveillance for drug resistance is ...
PROBLEM Many countries have limited experience of securing the best prices for drugs and have little negotiating power. This is particularly true for the complex, lengthy and expensive regimens used to treat multidrug-resistant tuberculosis. APPROACH The Stop TB Partnership's Global Drug Facility is dedicated to improving worldwide access to antituberculosis medicines and diagnostic technique...
Drugs for tuberculosis are inadequate to address the many inherent and emerging challenges of treatment. In the past decade, ten compounds have progressed into the clinical development pipeline, including six new compounds specifically developed for tuberculosis. Despite this progress, the global drug pipeline for tuberculosis is still insufficient to address the unmet needs of treatment. Addit...
In 2018, China contributed to 7.8% of the global drug innovation pipeline and 11.6% new launches, thereby becoming largest base for R&D in Asia. Statistically, oncology, particularly field lymphoma, occupies major area innovative development. Despite substantial advances, there is still an unmet need develop better therapies B-cell lymphomas (BCL), especially those incurable settings. As icon s...
Under the QSPR/QSAR paradigm, a comparative study is made of the known drug activity of as many as 15 anti-tubercular drugs vis-à-vis the computed quantum mechanical global reactivity descriptors like global hardness, global softness and global electrophilicity index. The comparative study reveals that the experimentally determined activity of drug molecules, including its variation with side s...
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