نتایج جستجو برای: gliomas

تعداد نتایج: 10988  

Journal: :Oncology 1998
W R Shapiro J R Shapiro

A large number of oncogenes have been identified as aberrant in gliomas, but only the erbB oncogene (gene encoding the epidermal growth factor receptor [EGFR]) is amplified in an appreciable number. The loss or mutation of tumor-suppressor genes located on different autosomes may be associated with progression of malignant gliomas. The p53 tumor-suppressor gene (located on chromosome 17) is fre...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Yong Luo Fan Wang Lv-An Chen Xiao-Wei Chen Zhi-Jun Chen Ping-Fei Liu Fen-Fen li Cai-Yan Li Wu Liang

Growing evidence shows that deregulation of the circadian clock plays an important role in the development of malignant tumors, including gliomas. However, the molecular mechanisms of gene chnages controlling circadian rhythm in glioma cells have not been explored. Using real time polymerase chain reaction and immunohistochemistry techniques, we examined the expression of two important clock ge...

2014
Yu-Chuan Hu Lin-Feng Yan Lang Wu Pang Du Bao-Ying Chen Liang Wang Shu-Mei Wang Yu Han Qiang Tian Ying Yu Tian-Yong Xu Wen Wang Guang-Bin Cui

The preoperative grading of gliomas, which is critical for guiding therapeutic strategies, remains unsatisfactory. We aimed to retrospectively assess the efficacy of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in the grading of gliomas. Forty-two newly diagnosed glioma patients underwent conventional MR imaging, DWI, and contrast-enhanced MR imaging. Parameters of appar...

2014
Ning Lin Wei Yan Kaiming Gao Yinyi Wang Junxia Zhang Yongping You

BACKGROUND Glioblastoma can be classified into four distinct molecular subtypes (Proneural, Neural, Classical and Mesenchymal), based on gene expression profiling. This study aimed to investigate the prevalence, clinicopathologic features and overall survival (OS) of the four molecular subtypes among all malignant gliomas. METHODS A total of 941 gene expression arrays with clinical data were ...

Journal: :Neuro-oncology 2014
Koki Aihara Akitake Mukasa Kengo Gotoh Kuniaki Saito Genta Nagae Shingo Tsuji Kenji Tatsuno Shogo Yamamoto Shunsaku Takayanagi Yoshitaka Narita Soichiro Shibui Hiroyuki Aburatani Nobuhito Saito

INTRODUCTION Mutations in H3F3A, which encodes histone H3.3, commonly occur in pediatric glioblastoma. Additionally, H3F3A K27M substitutions occur in gliomas that arise at midline locations (eg, pons, thalamus, spine); moreover, this substitution occurs mainly in tumors in children and adolescents. Here, we sought to determine the association between H3F3A mutations and adult thalamic glioma. ...

Journal: :Genetics and molecular research : GMR 2016
B Yang X Q Hao X W Zeng T L Ji S Pan Y G Feng

The chromosome 1p/19q deletion has been reported as a good prognosis marker for gliomas. However, the detection of 1p/19q status alone in glioma patients is not sufficient. The identification of a combination of molecular factors could effectively enhance the prediction accuracy. Thus far, the potential correlation between the 1p/19q status and vascular endothelial growth factor (VEGF) expressi...

Journal: :Genetics and molecular research : GMR 2016
X Gao Y J Tang G F Zhang L Yu S T Qi

We conducted a case-control study to investigate the role of ERCC2 rs13181 polymorphism in glioma development. A total of 165 patients who were histopathologically diagnosed to have gliomas and 330 controls were collected at Jiujiang First People's Hospital between July 2012 and June 2014. The ERCC2 rs13181 polymorphism was analyzed using a polymerase chain reaction -restriction fragment length...

2015
Kaspar Draaisma Maarten M. J. Wijnenga Bas Weenink Ya Gao Marcel Smid P. Robe Martin J. van den Bent Pim J. French

INTRODUCTION Recent advances in molecular diagnostics allow diffuse gliomas to be classified based on their genetic changes into distinct prognostic subtypes. However, a systematic analysis of all molecular markers has thus far not been performed; most classification schemes use a predefined and select set of genes/molecular markers. Here, we have analysed the TCGA dataset (combined glioblastom...

Journal: :World neurosurgery 2010
James L Frazier Michael W Johnson Peter C Burger Jon D Weingart Alfredo Quinones-Hinojosa

BACKGROUND Low-grade gliomas have been documented to undergo transformation into high-grade astrocytomas, and the time interval of this transformation has been reported to generally occur within 5 years in about 50% of patients harboring these low-grade lesions. Several studies have investigated the evolution of low-grade gliomas into malignant gliomas by CT and MRI characteristics, but many ha...

Journal: :Oncology reports 2015
Xiao-Peng Zhu Ke-Jie Mou Qing-Fu Xu Jun-Hai Tang Guo-Hao Huang Jian-Ping Xu Guang-Hui Li Si-Jin Ai Jean-Phillippe Hugnot Zheng Zhou Sheng-Qing Lv

Previous studies have focused on miRNA expression in brain gliomas. However, both the expression pattern of miRNAs in gliomas of different grades and various miRNAs involved in malignant progression of gliomas are poorly understood. In the present study, we used miRNA microarray-based screening to investigate the miRNA expression profile in gliomas, which was further verified by qRT-PCR in sele...

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