In the article by Pantalone et al. (1), the authors did not identify an increased total mortality risk among individual sulfonylureas (SUs)—glibenclamide versus glimepiride or glipizide—but did suggest that glimepiride may be the preferred SU in patients with history of coronary artery disease (CAD). The authors found that in a retrospective cohort of patients with CAD, the hazard ratio (HR) fo...

Inhibition of lipolysis by palmitate, H(2)O(2), and the antidiabetic sulfonylurea drug, glimepiride, in rat adipocytes has been shown previously to rely on the concerted degradation of cAMP by the glycosylphosphatidylinositol (GPI)-anchored phosphodiesterase Gce1 and 5'-nucleotidase CD73, which both gain access to the lipid droplets (LDs). The present report demonstrates the translocation of Gc...

OBJECTIVE We investigated the effect of glimepiride, a third-generation sulfonylurea hypoglycemic agent, on insulin resistance in elderly patients with type 2 diabetes, in connection with plasma adiponectin and 8-epi-prostagrandin F2alpha (8-epi-PGF2alpha), an oxidative stress marker. RESEARCH DESIGN AND METHODS A total of 17 elderly patients with type 2 diabetes received 12 weeks of treatmen...

Comparison effect of Pioglitazone and Glimepiride alone on renal function marker in experimentally induced damage diabetic rats.Jagdish Kakadiya, Nehal Shah

Comparison effect of Pioglitazone and Glimepiride alone on renal function marker in experimentally induced damage diabetic rats.Jagdish Kakadiya, Nehal Shah

Type 2 diabetes mellitus (T2DM) is a constantly progressing disease and monotherapy may last for approximately 5–10 years before a further increase in glycated hemoglobin (HbA1c) indicates the requirement of a combination therapy. We conducted a review focusing our attention on the effects of a combination of rosiglitazone plus glimepiride on metabolic control. We performed a defined search str...

AIMS/INTRODUCTION Dipeptidyl peptidase-4 inhibitors might have pleiotropic protective effects on cardiovascular disease (CVD), in contrast to sulfonylureas. Therefore, we compared various CVD risk factors between vildagliptin and glimepiride. MATERIALS AND METHODS We carried out a randomized, prospective and crossover trial. A total of 16 patients with type 2 diabetes whose glycated hemoglobi...

The aim of the present study was to investigate the effect of monotherapy with sitagliptin, or its combination with glimepiride in glycemic control, islet cell diameter and its proliferation in type 2 diabetic rats. Rats were fed with a high fat diet followed by injection with a low dose of streptozotocin to induce type 2 diabetes. Then, rats were switched to normal diet and for other 28 days. ...

CONTEXT Carotid artery intima-media thickness (CIMT) is a marker of coronary atherosclerosis and independently predicts cardiovascular events, which are increased in type 2 diabetes mellitus (DM). While studies of relatively short duration have suggested that thiazolidinediones such as pioglitazone might reduce progression of CIMT in persons with diabetes, the results of longer studies have bee...

Tamarind leaves (Tamarindus indica L.) are widely cultivated in tropical countries, including Indonesia. Empirically, tamarind known to have anti-diabetic properties. In this study, an in-silico method was used test the active compounds found as agents through docking score analysis. The target protein Protein Tyrosine Phosphatase (5JNT) which is related insulin resistance. Glimepiride and nati...