Background. Protective factors against Gleason upgrading and its impact on outcomes after surgery warrant better definition. Patients and Methods. Consecutive 343 patients were categorized at biopsy (BGS) and prostatectomy (PGS) as Gleason score, ≤6, 7, and ≥8; 94 patients (27.4%) had PSA recurrence, mean followup 80.2 months (median 99). Independent predictors of Gleason upgrading (logistic re...

Endothelial cell-specific molecule 1 (ESM1) is a major prognostic marker of several tumor types, but its value as a marker for prostate cancer is unknown. The purpose of the present study was to measure the relationship of ESM1 expression with androgen receptor (AR) expression and with Gleason score in human prostate carcinoma tissue. Expression of ESM1 and AR were determined by immunohistochem...

PURPOSE To retrospectively assess the utility of whole-lesion apparent diffusion coefficient (ADC) metrics in characterizing the Gleason 4 component of Gleason 7 prostate cancer (PCa) at radical prostatectomy. MATERIALS AND METHODS Seventy patients underwent phased-array coil 3T-magnetic resonance imaging (MRI) before prostatectomy. A uropathologist mapped locations and Gleason 4 percentage (...

A 64-year-old man with a prostate-specific antigen (PSA) of 5·74 ng/mL, no lower urinary symptoms, and family history prostate cancer presented at our clinic University College London Hospital (London, UK) in April, 2018. Axial T2-weighted MRI the showed multicystic lesion (PSA density 0·07 ng/mL/mL), MRI-targeted biopsies Gleason 3 + adenocarcinoma (Gleason Grade Group 1) prostatic intraepithe...

Taunton, UK There is no doubt that prostate cancer kills, but only a minority of men who are given this diagnosis, die from prostate cancer. In the developed world we are now overdiagnosing and, more importantly, overtreating prostate cancer, a fact for which we will be criticized in generations to come. As well-intentioned urologists, we should have no trouble in justifying our radical therapy...

PURPOSE There is a paucity of data on the prognosis after radical prostatectomy for Gleason score 9-10 disease on needle biopsy. To our knowledge we report the largest study to date to specifically analyze the correlation of Gleason score 9-10 on needle core biopsy with radical prostatectomy outcomes. MATERIALS AND METHODS We identified 259 men with Gleason score 9-10 on biopsy who underwent ...

PURPOSE Prostate cancer grading with Gleason score is an important prognostic factor. This prospective randomized study compares ultrasound systematic biopsy vs contrast enhanced color Doppler targeted biopsy for the impact on Gleason score findings. MATERIALS AND METHODS We examined 690 men (mean age 56 years, range 41 to 77) with a serum total prostate specific antigen of 1.25 ng/ml or grea...

Background: Unnecessary biopsies and overdiagnosis of prostate cancer (PCa) remain a serious healthcare problem. We have previously shown that urine- and plasma-based prostate-specific biomarkers when combined can predict high grade prostate cancer (PCa). To further validate this test, we performed a prospective multicenter study recruiting patients from community-based practices. Patients and ...

OBJECTIVE To differentiate prostate cancer lesions in transition zone by diffusion-weighted-MRI (DW-MRI). METHODS Data from a total of 63 patients who underwent preoperative DWI (b of 0-1000 s/mm2) were prospectively collected and processed by a monoexponential (DWI) model and compared with a biexponential (IVIM) model for quantitation of apparent diffusion coefficients (ADCs), perfusion frac...

Let Ω be a bounded domain in C. Let R(Ω) (usually A(Ω) or H(Ω)) be a ring of holomorphic functions that contains the polynomials, and let p = (p1, . . . , pn) be a point in Ω. Recall the Gleason problem, cf. [8]: is the maximal ideal in R(Ω) consisting of functions vanishing at p, generated by the coordinate functions (z1 − p1), . . . , (zn − pn) ? One says that a domain Ω has the Gleason R-pro...