Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and also affected the microtubule organization and migration ability in DU145 cells. GL did not induce double strand DNA break but activated the ATR and ATM-mediated DNA damage r...

Background: Acne is a chronic inflammatory skin disease and a cosmetic problem with considerable emotional and psychological side effects and symptoms, such as pain and pruritus. Some controversies exist concerning the involvement of dietary factors, including glycemic load (GL), in the pathogenesis of acne. Accordingly, we aimed to determine the role of GL and anthropometric m...

Getting lost (GL) is a serious problem for people living with Alzheimer's disease (PwAD), causing psychological distress in both PwAD and caregivers, and increasing the odds of being institutionalized. It is thus important to identify risk factors for the GL events in PwAD. Between April 2009 and March 2012, we invited 185 community-dwelling PwAD and their caregivers to participate in this stud...

This is an essay on potential theory for geometric plurisubharmonic functions. It begins with a given closed subset Gl of the Grassmann bundle G(p, TX) of tangent p-planes to a riemannian manifold X . This determines a nonlinear partial differential equation which is convex but never uniformly elliptic (p < dimX). A surprising number of results in complex analysis carry over to this more genera...

Glycolate(GL)-based polyesters were for the first time produced in the recombinant Escherichia coli fatty acid β-oxidation pathway reinforcing mutant LS5218, using extracellularly added GL as a monomer precursor. Cells expressing a Ser325Thr/Gln481Lys mutant of polyhydroxyalkanoate synthase (PhaC1STQK) from Pseudomonas sp. 61-3, propionyl-CoA transferase from Megasphaera elsdenii and enoyl-CoA ...

We propose algorithms to get representatives and the images of the moment map of conormal bundles of GL(p,C)×GL(q,C)-orbits in the flag variety of GL(p+q,C), and GL(p+q,C)-orbits and Sp(p,C)×Sp(q,C)-orbits in the flag variety of Sp(p+ q,C) and their signed Young diagrams.

This work concerns linear multiplicity free actions of the complex groups GC = GL(n,C), GL(n,C) × GL(n,C) and GL(2n,C) on the vector spaces V = Sym(n,C), Mn(C) and Skew(2n,C). We relate the canonical invariants in C[V ⊕ V ∗] to spherical functions for Riemannian symmetric pairs (G,K) where G = GL(n,R), GL(n,C) or GL(n,H) respectively. These in turn can be expressed using three families of class...

UNLABELLED BACKGROUND Dietary glycemic index or load is thought to play an important role in glucose metabolism. However, few studies have investigated the relation between glycemic index (GI) or load (GL) and glycemia in Asian populations. In this cross-sectional analysis of a randomized controlled trial, the Saku Control Obesity Program, we examined the relation between the baseline GI or ...

Let Gl be the graph obtained from Kl by adhering the root of isomorphic trees T to every vertex of Kl, and dk−j+1 be the degree of vertices in the level j. In this paper we study the spectrum of the adjacency matrix A(Gl) and the Laplacian matrix L(Gl) for all positive integer l, and give some results about the spectrum of the adjacency matrix A(Gl) and the Laplacian matrix L(Gl). By using thes...