نتایج جستجو برای: gk model

تعداد نتایج: 2106445  

2014
Xiaotian Zhang Yi Wang Wenjing Hu Dongye Li Zhongmin Zhou Defeng Pan Wanling Wu Tongda Xu

The value of restenosis after percutaneous coronary intervention (PCI) is recognized worldwide, especially for diabetic patients. Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether and how the IL-1/TLR-induced nuclear factor kappa B (NFκB) pathway plays key roles in intimal formation is unclear. The underlying mechanism of inti...

Journal: :The Biochemical journal 1999
C V Burke C W Buettger E A Davis S J McClane F M Matschinsky S E Raper

Mutations in the glucokinase (GK) gene cause type-2 maturity-onset diabetes of the young type 2 (MODY-2) and GK-linked hyperinsulinaemia (GK-HI). Recombinant adenoviruses expressing the human wild-type islet GK or one of four mutant forms of GK, (the MODY-2 mutants E70K, E300K and V203A and the GK-HI mutant V455M) were transduced into glucose-responsive insulin-secreting beta-HC9 cells and test...

2014
Bogumil Zelent Anne Raimondo Amy Barrett Carol W. Buettger Pan Chen Anna L. Gloyn Franz M. Matschinsky

Hepatic glucose phosphorylation by GK (glucokinase) is regulated by GKRP (GK regulatory protein). GKRP forms a cytosolic complex with GK followed by nuclear import and storage, leading to inhibition of GK activity. This process is initiated by low glucose, but reversed nutritionally by high glucose and fructose or pharmacologically by GKAs (GK activators) and GKRPIs (GKRP inhibitors). To study ...

2017
Md Rashedunnabi Akanda In-Shik Kim Dongchoon Ahn Hyun-Jin Tae Weishun Tian Hyeon-Hwa Nam Byung-Kil Choo Byung-Yong Park

Geranium koreanum (GK) is an indigenous Chinese herbal medicine widely used for the treatment of various inflammation and liver disorders. However, the exact mechanism of action of GK remains unknown. This study aimed to investigate the protective effect and related molecular mechanism of GK on NaAsO2-induced cytotoxicity in HepG2 cells and liver damage in mice. The cytoprotective role of GK wa...

Journal: :Journal of virology 2008
Timothy P Foster Vladimir N Chouljenko K G Kousoulas

Herpes simplex virus type 1 glycoprotein K (gK) and the UL20 protein (UL20p) are coordinately transported to the trans-Golgi network (TGN) and cell surfaces and are required for cytoplasmic virion envelopment at the TGN. In addition, cell surface expression of gK and UL20p is required for virus-induced cell fusion. Previously, confocal microscopy colocalization and intracellular transport exper...

Journal: :Journal of virology 2015
Nithya Jambunathan Anu-Susan Charles Ramesh Subramanian Ahmad A Saied Misagh Naderi Paul Rider Michal Brylinski Vladimir N Chouljenko Konstantin G Kousoulas

UNLABELLED We have shown previously that herpes simplex virus 1 (HSV-1) lacking expression of the entire glycoprotein K (gK) or expressing gK with a 38-amino-acid deletion (gKΔ31-68 mutation) failed to infect ganglionic neurons after ocular infection of mice. We constructed a new model for the predicted three-dimensional structure of gK, revealing that the gKΔ31-68 mutation spans a well-defined...

2014
Sophie Calderari Jean-Claude Irminger Marie-Hélène Giroix Jan A. Ehses Marie-Noëlle Gangnerau Josiane Coulaud Katharina Rickenbach Dominique Gauguier Philippe Halban Patricia Serradas Françoise Homo-Delarche

Regenerating (REG) proteins are associated with islet development, β-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved in cell growth/survival and/or inflammation and the Reg1 promoter contains interleukin-6 (IL-6)-responsive elements. We showed by transcriptome analysis that islets of Goto-Kakizaki (GK) rats, a model of spontaneous type 2 diabetes, overexp...

2012
Hiroki Mizukami Wataru Inaba Kazunori Takahashi Keisuke Inoue Kimio Sawanobori Soroku Yagihashi

UNLABELLED Aims/Introduction:  High fat diet (HFD) is known to be a risk for development of type 2 diabetes. It is unclear, however, how it affects the glucose tolerance or the islet structure in type 2 diabetes. The aim of this study is: (i) to examine the effects of HFD on the islet in GK rats, non-obese type 2 diabetic model; and (ii) to explore if pitavastatin treatment influences the chang...

2018
Jaime Cuevas Italo Granato Roberto Fritsche-Neto Osval A Montesinos-Lopez Juan Burgueño Massaine Bandeira E Sousa José Crossa

In this study, we compared the prediction accuracy of the main genotypic effect model (MM) without G×E interactions, the multi-environment single variance G×E deviation model (MDs), and the multi-environment environment-specific variance G×E deviation model (MDe) where the random genetic effects of the lines are modeled with the markers (or pedigree). With the objective of further modeling the ...

Journal: :The Biochemical journal 2002
Ulrike Roth Kurt Jungermann Thomas Kietzmann

Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator ...

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