While connexins (Cxs) are thought to be involved in differentiation, their expression and role has yet to be fully elucidated. We investigated the temporal expression of Cx30, Cx36 and Cx43 in two in vitro models of neuronal differentiation: human NT2/D1 and murine P19 cells, and the spatial localisation of Cx30 and Cx43 in these models. A temporal Cx43 downregulation was confirmed in both cell...

The neutrino is involved in many of the unsolved areas of fundamental physics and cosmology, and therefore a better understanding of the causes of its behaviour is useful. This paper develops a conceptual theory for the internal structure of the neutrino, particularly the arrangement of its discrete field structures. The model is created using the concept of the cordus hyff emission directions ...

The asteroid 4 Vesta is the only known differentiated asteroid with an intact internal structure, probably consisting of a metal core, an ultramafic mantle, and a basaltic crust. Considerable evidence suggests that the HED meteorites are impact ejecta from Vesta, and detailed studies of these meteorites in terrestrial laboratories, combined with ever more sophisticated remote sensing studies of...

BACKGROUND AND PURPOSE Dupuytren's disease (DD) is a benign fibroproliferative process of the palmar aponeurosis showing similarities to wound healing. Communication of cells involved in wound healing is mediated by the composition of gap junction (GJ) proteins. We investigated the expression of 3 GJ proteins, connexins 26, 30, and 43 (Cx26, Cx30, and Cx43) in DD. PATIENTS AND METHODS Fragmen...

Connexins are a family of proteins that assemble to form gap junction channels. Cell-cell communication through gap junctions mediates many important events in embryogenesis, including limb patterning, lens physiology, neuronal function, left-right asymmetry, and secretion from gland tissue. We studied the expression of connexin 30 (Cx30) in the Xenopus embryo and find that it is expressed in t...

Astroctyes express a set of three connexins (Cx26, Cx30, and Cx43) that are contained in astrocyte-to-astrocyte (A/A) gap junctions; oligodendrocytes express a different set of three connexins (Cx29, Cx32, and Cx47) that are contained in the oligodendrocyte side of necessarily heterotypic astrocyte-to-oligodendrocyte (A/O) gap junctions, and there is little ultrastructural evidence for gap junc...