Polyprenol (GBP) from Ginkgo biloba Leaves (GBL) is an important lipid with many bioactive effects. The effect of GBP on antibacterial properties of five antibiotics belonging to different classes was through analysis of inhibition halos, MIC, and FIC index. And we studied the time-killing curves and Ca(2+) mobilization assay in Staphylococcus aureus cells treated with GBP microemulsion and gen...

BACKGROUND Impairment of cognitive function as well as negative symptom is the major factor causing the decline of a patient's functioning in chronic stages of schizophrenia. However, until now, there were no definite treatment options that could effectively reduce the impairment. CASE PRESENTATION We report a case of mood dysregulation associated with use of Ginkgo biloba in a patient with s...

BACKGROUND The benefit of Ginkgo biloba has been discussed controversially. The aim of this review was to assess the effects of Ginkgo biloba in Alzheimer's disease as well as vascular and mixed dementia covering a variety of outcome domains. METHODS We searched MEDLINE, EMBASE, the Cochrane databases, CINAHL and PsycINFO for controlled trials of ginkgo for Alzheimer's, vascular or mixed deme...

One of the most remarkable things about the ancient tree, Ginkgo biloba L., is its resistance to pests and disease (1). Although some effort has been made in the past to find substances in parts of G. biloba L. which might account for this resistance, no success seems to have attended these efforts (2-4). A systematic examination of various parts of G. biloba L. has been undertaken in order to ...

The aim of the study was to perform a quantitative analysis of fluid extracts of maidenhair tree (Ginkgo biloba L.), motherwort (Leonurus cardiaca L.) and hawthorn (Crataegus monogyna Jacq.), to evaluate their antioxidant activity and to compare their ability to inactivate free radicals. The antioxidant activity was measured using the DPPH*and the ABTS*+ radical scavenging reaction systems. The...

Pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a role not only in drug metabolism and transport but also in various other biological processes. Ginkgo biloba is a herbal medicine commonly used to manage memory impairment. Treatment of primary cultures of rat hepatocytes with G. biloba extract increases the mRNA expression of CYP3A23, which is a target gen...

Ginkgo biloba is widely used in folk medicine. Patients very often use the plant preparation with no concern for purity. They also tend to increase the dosage by themselves and this may result in certain insufficiently researched acute effects. Due to this extremely widespread application, the aim of this work is an examination of the possible acute effects of Ginkgo bilobaon the motility of th...

JAMES H. FISHER,1 VLADIMIR SHEFTELYEVICH,1 YE-SHIH HO,2 SUZANNE FLIGIEL,3 FRANCIS X. MCCORMACK,4 THOMAS R. KORFHAGEN,5 JEFFREY A. WHITSETT,5 AND MACHIKO IKEGAMI5 1Pulmonary/Critical Care Medicine, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262; 5Division of Pulmonary Biology, Children’s Hospital Medical Center, and 4Pulmonary and Critical ...

Li-Fen Hu, M.D., Xi-Hai Xu, M.D., Hai-Fei Yang, M.D., Ying Ye, M.D., and Jia-Bin Li, M.D. Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University; Anhui Center for Surveillance of Bacterial Resistance; Department of Center Laboratory, the First Affiliated Hospital of Anhui Medical University; Department of Infectious Diseases, the Chaohu Affiliated Hospital ...