BACKGROUND Cardiovascular disease (CVD) was a preplanned secondary outcome of the Ginkgo Evaluation of Memory Study. The trial previously reported that Ginkgo biloba had no effect on the primary outcome, incident dementia. METHODS AND RESULTS The double-blind trial randomly assigned 3069 participants over 75 years of age to 120 mg of G biloba EGb 761 twice daily or placebo. Mean follow-up was...

The seeds of Ginkgo biloba are commonly eaten in Japan, Korea and China, but it is important to know that they can be responsible for poisoning, especially in young children. Poisoning due to Ginkgo biloba seeds must also be considered as a possible clinical event in European countries, where Asian cuisine has recently become popular. This paper reports the case of a 23-months-old previously he...

Autumnal tints are one of the most fascinating natural phenomena, but the molecular mechanism of chlorophyll (Chl-)degradation in deciduous trees has not been fully understood. In this study, from the leaves of Ginkgo biloba, chlorophyllase-homologous GbCLH was cloned by RT-PCR with degenerated primers. The expression of GbCLH in different yellowing stages was analyzed by Northern hybridization...

A rapid microwave-assisted hydrolysis (MAH) method is presented for the sample pretreatment of the determination of ginkgo flavonol glycosides in extracts of Ginkgo biloba L. (EGb). By this method, flavonol glycosides can be completely hydrolyzed within 2 min. After investigating the effects of solvents, acidity, microwave power, and microwave radiation time on hydrolysis, the optimal hydrolysi...

BACKGROUND The benefit of Ginkgo biloba has been discussed controversially. The aim of this review was to assess the effects of Ginkgo biloba in Alzheimer's disease as well as vascular and mixed dementia covering a variety of outcome domains. METHODS We searched MEDLINE, EMBASE, the Cochrane databases, CINAHL and PsycINFO for controlled trials of ginkgo for Alzheimer's, vascular or mixed deme...

background: multiple sclerosis (ms) is a chronic demyelinating disease that can affect cognitive function. the purpose of this study was to assess the efficacy of ginkgo biloba (gb) on improvement of memory impairment and quality of life in patients with ms. methods: this study was an 8-week, open study of patients with ms. thirty patients was recruited from a variety of outpatient settings. al...

We report on a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency who developed acute hemolytic anemia after having received an injection of Ginkgo biloba for dementia prophylaxis without medical advice. She suddenly developed general malaise, generalized yellowish skin color, and tea-colored urine. Intravenous fluid infusion and cessation of G. biloba quickly relieved her clinica...

Objective(s): In this work, Ginkgo biloba extract (GBE) loaded solid lipid nanoparticles (SLNs) were synthesized via high pressure homogenization method and their physicochemical properties, as well as cytotoxicity and antibacterial activities were evaluated.Methods: Ginkgo biloba extract SLNs (GBE-SLNs) were prepared using high pressure homogenization method. The morphology and size of S...

In the present study, we investigated the effect of Ginkgo biloba extracts and some of its individual constituents on the catalytic activity of human cytochrome P450 enzymes CYP1B1, CYP1A1, and CYP1A2. G. biloba extract of known abundance of terpene trilactones and flavonol glycosides inhibited 7-ethoxyresorufin O-dealkylation catalyzed by human recombinant CYP1B1, CYP1A1, and CYP1A2, and human...

Stress is a global menace fortified by the advancement of industrialization. Failure of stress management is due to lack of proper evaluation of anti-stress products. We explored the anti-stress potential of the Ginkgo biloba (G. biloba, 30 mg/kg, p.o.) and compared it with that of Panax ginseng (P. ginseng, 100 mg/kg, p.o.) against acute stress (AS) and chronic stress (CS) models in rats. Imme...